Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 known ✓ | P30556 | 1/20 | 0.58 |
| ▸ | AKT1 | P31749 | 3/20 | 0.58 |
| ▸ | CDC25A | P30304 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | ESR1 | P03372 | 1/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.47 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.47 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | PRKCG | P05129 | 1/20 | 0.46 |
| ▸ | PRKCB | P05771 | 1/20 | 0.46 |
| ▸ | PRKCA | P17252 | 1/20 | 0.46 |
| ▸ | PRKCH | P24723 | 1/20 | 0.46 |
| ▸ | PRKCI | P41743 | 1/20 | 0.46 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.46 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.46 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL28791017 | 1.00 | AKT1 (0.58) | AKT1CDC25ALMNAESR1ADORA3 | |
| SCHEMBL26655434 | 0.97 | AKT1 (0.58) | AKT1CDC25ALMNAESR1ADORA3 | |
| Potassium Ion SCHEMBL28791049 | 0.93 | CDC25A (0.47) | AKT1CDC25ALMNAESR1ADORA3 | |
| Potassium Ion SCHEMBL10435762 | 0.91 | CDC25A (0.44) | AKT1CDC25ALMNAESR1ADORA3 | |
| Potassium Ion SCHEMBL28354726 | 0.90 | AKT1 (0.46) | AKT1CDC25ALMNAESR1ADORA3 | |
| Hexadecyl Dihydrogen Phosphate SCHEMBL17685324 | 0.90 | LPAR3 (0.47) | AKT1CDC25ALMNAESR1ADORA3 | |
| SCHEMBL26654808 | 0.89 | CDC25A (0.47) | AKT1CDC25ALMNAESR1ADORA3 | |
| SCHEMBL10435660 | 0.89 | CDC25A (0.47) | AKT1CDC25ALMNAESR1ADORA3 | |
| SCHEMBL8821269 | 0.89 | CDC25A (0.47) | AKT1CDC25ALMNAESR1ADORA3 | |
| Zinc Ion SCHEMBL2184087 | 0.89 | CDC25A (0.47) | AKT1CDC25ALMNAESR1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3367996-A1 | NOVEL OCCLUSIVE COMPOSITIONS | GlaxoSmithKline Consumer Healthcare Holdings (US) LLC (US) | 2018-09-05 | — | — | EP | disclosed |
| WO-2017074892-A1 | NOVEL OCCLUSIVE COMPOSITIONS | GLAXOSMITHKLINE CONSUMER HEALTHCARE HOLDINGS (US) LLC (US) | 2017-05-04 | — | — | WO | disclosed |