Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.35 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24904423 | 0.76 | TRPV1 (0.43) | MAPTLMNARAB9AHTTSMN1; SMN2 | |
| SCHEMBL18798745 | 0.72 | HRH3 (0.34) | ALDH1A1 | |
| SCHEMBL12463520 | 0.72 | CYP19A1 (0.39) | RAB9AHPGDALDH1A1NPC1TDP1 | |
| SCHEMBL12877492 | 0.72 | CHRNB4 (0.40) | LMNAGAAALDH1A1TDP1HSD17B10 | |
| SCHEMBL397351 | 0.71 | HSD17B10 (0.56) | MAPTLMNARAB9AHTTSMN1; SMN2 | |
| SCHEMBL6223902 | 0.68 | ALDH1A1 (0.54) | MAPTLMNARAB9AMEN1KMT2A | |
| SCHEMBL9571113 | 0.68 | CHRNB4 (0.44) | LMNASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL394201 | 0.67 | LOXL2 (0.52) | MAPTALDH1A1HSD11B1POLBACHE | |
| SCHEMBL428785 | 0.67 | ALDH1A1 (0.49) | MAPTALDH1A1TDP1HSD11B1POLB | |
| SCHEMBL8743939 | 0.67 | SHBG (0.52) | MAPTSMN1; SMN2ALDH1A1HSD11B1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9637491-B2 | Pyrazolo[4,3-D]pyrimidines as kinase inhibitors | ORIGENIS GMBH (DE) | 2017-05-02 | — | — | US | disclosed |