Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 5/20 | 0.62 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800659 | 0.91 | BTK (0.51) | BTKSMN1; SMN2HPGDPLAUMCL1 | |
| SCHEMBL18800820 | 0.90 | BTK (0.51) | BTKCHEK2F2F10SMN1; SMN2 | |
| SCHEMBL16168188 | 0.89 | ALDH1A1 (0.53) | BTKSMN1; SMN2HPGDMCL1MAPT | |
| SCHEMBL16168193 | 0.89 | PARP10 (0.51) | BTKCHEK2F2MCL1XDH | |
| SCHEMBL18800685 | 0.87 | BTK (0.64) | BTKF2SMN1; SMN2HTTMCL1 | |
| SCHEMBL18800407 | 0.87 | F2 (0.49) | BTKF2F10PLAUMCL1 | |
| SCHEMBL18800779 | 0.87 | XDH (0.47) | BTKMCL1NPC1RAB9AXDH | |
| SCHEMBL18800673 | 0.87 | PGR (0.53) | BTKF2HDAC3BRAFHDAC4 | |
| SCHEMBL16168190 | 0.87 | BTK (0.54) | BTKF10ALDH1A1ATRMMP13 | |
| SCHEMBL18800684 | 0.86 | BTK (0.47) | BTKF2SMN1; SMN2HPGDHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |