Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.64 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.42 |
| ▸ | THRA | P10827 | 6/20 | 0.42 |
| ▸ | THRB | P10828 | 6/20 | 0.42 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | ASPH | Q12797 | 1/20 | 0.40 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.40 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800659 | 0.90 | BTK (0.51) | BTKSMN1; SMN2MCL1 | |
| SCHEMBL16168190 | 0.90 | BTK (0.54) | BTKPRSS1MMP13KDM4E | |
| SCHEMBL18800612 | 0.89 | BTK (0.52) | BTKF2PRSS1TMPRSS15MMP1 | |
| SCHEMBL18800413 | 0.87 | BTK (0.62) | BTKF2HTTMMP13SMN1; SMN2 | |
| SCHEMBL16168193 | 0.86 | PARP10 (0.51) | BTKF2PRSS1MCL1 | |
| SCHEMBL18800407 | 0.85 | F2 (0.49) | BTKF2PRSS1MCL1 | |
| SCHEMBL18800779 | 0.85 | XDH (0.47) | BTKMCL1 | |
| SCHEMBL18800673 | 0.85 | PGR (0.53) | BTKF2PRSS1 | |
| SCHEMBL16168188 | 0.84 | ALDH1A1 (0.53) | BTKSMN1; SMN2MCL1MAPT | |
| SCHEMBL18800677 | 0.84 | MCL1 (0.46) | BTKLMNAMCL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |