Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.44 |
| ▸ | BTK | Q06187 | 5/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 3/20 | 0.40 |
| ▸ | PLAT | P00750 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16168188 | 0.92 | ALDH1A1 (0.53) | ALDH1A1GLAHPGDSMN1; SMN2NPSR1 | |
| SCHEMBL18800817 | 0.90 | TNK2 (0.52) | TNK2BTKMCL1 | |
| SCHEMBL18800890 | 0.87 | TNK2 (0.48) | TNK2BTKPLATMCL1 | |
| SCHEMBL18800896 | 0.86 | MCL1 (0.47) | TNK2BTKPLAUMCL1 | |
| SCHEMBL18800677 | 0.85 | MCL1 (0.46) | ALDH1A1BTKMCL1MAPTTDP1 | |
| SCHEMBL18800806 | 0.84 | BTK (0.49) | ALDH1A1GLAHPGDTNK2BTK | |
| SCHEMBL18800404 | 0.84 | NPC1 (0.53) | SMN1; SMN2TNK2 | |
| SCHEMBL18800779 | 0.84 | XDH (0.47) | BTKMCL1 | |
| SCHEMBL18800803 | 0.83 | SCN9A (0.48) | BTKPLAUCA12CA1CA2 | |
| SCHEMBL16168193 | 0.83 | PARP10 (0.51) | TNK2BTKMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |