Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 3/20 | 0.52 |
| ▸ | BTK | Q06187 | 5/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 2/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800663 | 0.90 | ALDH1A1 (0.47) | TNK2BTKMCL1 | |
| SCHEMBL18800677 | 0.89 | MCL1 (0.46) | BTKMCL1SCN9A | |
| SCHEMBL18800664 | 0.89 | BTK (0.47) | TNK2BTKMCL1SCN9ADHODH | |
| SCHEMBL18800806 | 0.88 | BTK (0.49) | TNK2BTKMCL1 | |
| SCHEMBL18800404 | 0.88 | NPC1 (0.53) | TNK2F10F2 | |
| SCHEMBL18800779 | 0.88 | XDH (0.47) | BTKMCL1SCN9A | |
| SCHEMBL16168193 | 0.87 | PARP10 (0.51) | TNK2BTKMCL1F2CHEK2 | |
| SCHEMBL18800890 | 0.86 | TNK2 (0.48) | TNK2BTKMCL1P2RX3 | |
| SCHEMBL18800613 | 0.86 | MCL1 (0.53) | TNK2BTKMCL1 | |
| SCHEMBL18800896 | 0.86 | MCL1 (0.47) | TNK2BTKMCL1F10F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |