Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ST14 | Q9Y5Y6 | 10/20 | 0.47 |
| ▸ | F2 | P00734 | 8/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 6/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 6/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | PLG | P00747 | 2/20 | 0.44 |
| ▸ | ATR | Q13535 | 2/20 | 0.44 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.43 |
| ▸ | DCK | P27707 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800817 | 0.88 | TNK2 (0.52) | F2F10TNK2 | |
| SCHEMBL18780383 | 0.86 | NPC1 (0.54) | NPC1PKMST14F2PRSS1 | |
| SCHEMBL18800663 | 0.84 | ALDH1A1 (0.47) | TNK2SMN1; SMN2 | |
| SCHEMBL18800896 | 0.84 | MCL1 (0.47) | F2F10TNK2 | |
| SCHEMBL18800677 | 0.81 | MCL1 (0.46) | NPC1MEN1RAB9AKMT2A | |
| SCHEMBL18800806 | 0.81 | BTK (0.49) | TNK2MEN1KMT2A | |
| SCHEMBL18800673 | 0.81 | PGR (0.53) | F2PRSS1PLGMEN1RAB9A | |
| SCHEMBL12875252 | 0.80 | GCK (0.42) | NPC1TNK2MEN1RAB9AKMT2A | |
| SCHEMBL18800779 | 0.80 | XDH (0.47) | NPC1RAB9A | |
| SCHEMBL18800659 | 0.80 | BTK (0.51) | MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |