Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 4/20 | 0.46 |
| ▸ | F10 | P00742 | 7/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.42 |
| ▸ | F2 | P00734 | 3/20 | 0.41 |
| ▸ | BTK | Q06187 | 4/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | TEK | Q02763 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800831 | 0.89 | TNK2 (0.50) | F10TNK2F2BTK | |
| SCHEMBL18800881 | 0.89 | F10 (0.46) | IGF1RF10TNK2F2BTK | |
| SCHEMBL18800691 | 0.86 | BTK (0.43) | F10TNK2BTK | |
| SCHEMBL18800635 | 0.83 | BTK (0.48) | TNK2BTK | |
| SCHEMBL18800914 | 0.82 | CFD (0.45) | CDK1MKNK2 | |
| SCHEMBL18800692 | 0.82 | TEK (0.35) | IGF1RF10F2KCNA5TEK | |
| SCHEMBL18800767 | 0.81 | RAB9A (0.48) | F10TNK2BTK | |
| SCHEMBL6116531 | 0.79 | BTK (0.61) | IGF1RTNK2BTK | |
| SCHEMBL18800755 | 0.78 | TNK2 (0.50) | F10TNK2F2BTK | |
| SCHEMBL18800411 | 0.76 | BTK (0.56) | TNK2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |