Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 3/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 6/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | DDT | P30046 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800691 | 0.90 | BTK (0.43) | TNK2BTKF10 | |
| SCHEMBL18800693 | 0.89 | IGF1R (0.46) | TNK2BTKF2F10 | |
| SCHEMBL18800755 | 0.88 | TNK2 (0.50) | TNK2AKR1C3BTKF2F10 | |
| SCHEMBL18800635 | 0.87 | BTK (0.48) | TNK2BTK | |
| SCHEMBL18800914 | 0.86 | CFD (0.45) | AKR1C3MAP4K4CHEK2NR1H4AXL | |
| SCHEMBL18800767 | 0.85 | RAB9A (0.48) | TNK2BTKF10MAP4K4 | |
| SCHEMBL18800829 | 0.81 | TNK2 (0.34) | TNK2F2F10MAP4K4FEN1 | |
| SCHEMBL18800757 | 0.81 | TNK2 (0.49) | TNK2BTKMAP4K4FEN1 | |
| SCHEMBL18800411 | 0.80 | BTK (0.56) | TNK2BTK | |
| SCHEMBL18800817 | 0.79 | TNK2 (0.52) | TNK2AKR1C3BTKF2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |