Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | F10 | P00742 | 2/20 | 0.46 |
| ▸ | ATR | Q13535 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | ROS1 | P08922 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800831 | 0.85 | TNK2 (0.50) | F10MAP4K4BTKTNK2 | |
| SCHEMBL18800556 | 0.84 | ATR (0.44) | F10ATRALDH1A1HPGDPARP14 | |
| SCHEMBL18780338 | 0.82 | RAB9A (0.50) | RAB9AMEN1KMT2AF10ATR | |
| SCHEMBL18800691 | 0.82 | BTK (0.43) | F10ALDH1A1BTKTNK2 | |
| SCHEMBL18800693 | 0.81 | IGF1R (0.46) | F10BTKTNK2 | |
| SCHEMBL6116481 | 0.80 | BTK (0.55) | RAB9AMEN1KMT2AATRALDH1A1 | |
| SCHEMBL18800635 | 0.79 | BTK (0.48) | BTKTNK2 | |
| SCHEMBL18800914 | 0.78 | CFD (0.45) | RAB9AKMT2AALDH1A1HPGDJAK2 | |
| SCHEMBL18800807 | 0.76 | ATR (0.48) | RAB9AF10ATRALDH1A1HPGD | |
| SCHEMBL18800755 | 0.74 | TNK2 (0.50) | F10MAP4K4BTKTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |