Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1647924 | 0.91 | LMNA (0.47) | LMNAMAPTMAPK1MEN1ALOX5 | |
| SCHEMBL1648072 | 0.88 | MAPT (0.47) | LMNAMAPTMAPK1MEN1ALOX5 | |
| SCHEMBL18801282 | 0.87 | KMT2A (0.43) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL18801109 | 0.82 | MAPT (0.47) | LMNAMAPTMAPK1MEN1ALOX5 | |
| SCHEMBL18801347 | 0.81 | L3MBTL1 (0.48) | LMNAMAPTMAPK1MEN1ALOX5 | |
| SCHEMBL18801162 | 0.81 | NPC1 (0.41) | LMNAMAPTMAPK1MEN1ALOX5 | |
| SCHEMBL18801108 | 0.79 | ALOX5 (0.48) | LMNAMAPTMAPK1MEN1ALOX5 | |
| SCHEMBL18801058 | 0.79 | ALOX5 (0.48) | LMNAMAPTMAPK1ALOX5NPC1 | |
| SCHEMBL28104591 | 0.79 | ALDH1A1 (0.51) | LMNAMAPTMAPK1MEN1ALOX5 | |
| SCHEMBL18801417 | 0.78 | KMT2A (0.44) | MEN1KMT2ANPC1RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486004-B1 | SULPHONE COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | ZAFGEN INC (US) | 2017-05-03 | — | — | EP | disclosed |