Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18801321 | 0.89 | TSHR (0.35) | GAATSHRMAPK1NPC1RAB9A | |
| SCHEMBL18801131 | 0.82 | HTT (0.31) | HTT | |
| SCHEMBL18801147 | 0.80 | METAP2 (0.48) | HTT | |
| SCHEMBL18801291 | 0.78 | IMPDH2 (0.42) | — | |
| SCHEMBL1647720 | 0.78 | METAP2 (0.44) | HTT | |
| SCHEMBL18801252 | 0.78 | MEN1 (0.30) | — | |
| SCHEMBL18801070 | 0.78 | TUBB4A (0.39) | DGAT2GAATSHRRAB9A | |
| SCHEMBL1649154 | 0.78 | NPC1 (0.38) | DGAT2NPC1RAB9A | |
| SCHEMBL18801161 | 0.78 | MAPT (0.37) | GAANPC1RAB9A | |
| SCHEMBL18801484 | 0.76 | TUBB4A (0.38) | GAANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486004-B1 | SULPHONE COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | ZAFGEN INC (US) | 2017-05-03 | — | — | EP | disclosed |