Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 7/20 | 0.36 |
| ▸ | CDK8 | P49336 | 7/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24522190 | 0.84 | TMEM97 (0.39) | SMN1; SMN2HPGDPOLBCCNCCDK8 | |
| SCHEMBL18801701 | 0.78 | SMN1; SMN2 (0.41) | SMN1; SMN2HPGDPOLBCCNCCDK8 | |
| SCHEMBL18801728 | 0.70 | CHRNB2 (0.49) | — | |
| SCHEMBL18801607 | 0.67 | HPGD (0.42) | SMN1; SMN2HPGDKMT2AGAAHSD17B10 | |
| SCHEMBL24522216 | 0.64 | SMN1; SMN2 (0.53) | SMN1; SMN2HPGDPOLBKMT2A | |
| SCHEMBL17805452 | 0.62 | GPBAR1 (0.40) | SMN1; SMN2 | |
| SCHEMBL2707270 | 0.62 | CCNC (0.50) | SMN1; SMN2CCNCCDK8KMT2A | |
| SCHEMBL3666059 | 0.61 | RIPK1 (0.44) | SMN1; SMN2HPGD | |
| SCHEMBL24522211 | 0.60 | SMN1; SMN2 (0.39) | SMN1; SMN2HPGDKMT2A | |
| SCHEMBL29892279 | 0.60 | CCNC (0.51) | SMN1; SMN2CCNCCDK8KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585064-B1 | C5AR ANTAGONISTS | CHEMOCENTRYX INC (US) | 2017-05-03 | — | — | EP | disclosed |