Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | GLA | P06280 | 2/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16027801 | 0.82 | SNCA (0.35) | ALOX5POLB | |
| SCHEMBL27878809 | 0.80 | ALOX5 (0.35) | ALOX5POLBPKMKDM4EGAA | |
| SCHEMBL17336323 | 0.74 | EGLN1 (0.39) | LMNA | |
| SCHEMBL17336334 | 0.72 | PTGDR2 (0.39) | ABCB11 | |
| SCHEMBL6058682 | 0.72 | TDP1 (0.50) | ALDH1A1MAPK1SMN1; SMN2ALOX5KDM4E | |
| SCHEMBL16028104 | 0.70 | FFAR1 (0.34) | — | |
| SCHEMBL27703245 | 0.70 | LMNA (0.38) | ALDH1A1MAPK1SMN1; SMN2ALOX5KDM4E | |
| SCHEMBL4949836 | 0.70 | KDM4E (0.35) | ALDH1A1MAPK1SMN1; SMN2ALOX5POLB | |
| SCHEMBL17607619 | 0.70 | ALDH1A1 (0.46) | ALDH1A1MAPK1SMN1; SMN2POLBPKM | |
| SCHEMBL31586748 | 0.70 | NPSR1 (0.44) | ALDH1A1MAPK1SMN1; SMN2POLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9738653-B2 | Fused furans for the treatment of hepatitis C | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-08-22 | — | — | US | disclosed |
| EP-2970174-B1 | FUSED FURANS FOR THE TREATMENT OF HEPATITIS C | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |