Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | APLNR | P35414 | 2/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9852982 | 0.79 | PDPK1 (0.43) | PDPK1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7199405 | 0.73 | ALDH1A1 (0.39) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL28496069 | 0.71 | PDPK1 (0.38) | PDPK1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL1660459 | 0.71 | LMNA (0.36) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8840393 | 0.67 | SMN1; SMN2 (0.33) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL21719080 | 0.67 | PDPK1 (0.35) | PDPK1CD274 | |
| SCHEMBL16395233 | 0.67 | HSD17B10 (0.38) | PDPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL13064175 | 0.67 | AGXT (0.33) | — | |
| SCHEMBL30871925 | 0.67 | TDP1 (0.35) | — | |
| SCHEMBL8889229 | 0.67 | TDP1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2167489-B1 | PYRIMIDINE DERIVATIVES USEFUL AS RAF KINASE INHIBITORS | SUNESIS PHARMACEUTICALS INC (US) | 2017-05-03 | — | — | EP | disclosed |