Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.76 |
| ▸ | MMP2 | P08253 | 1/20 | 0.72 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.61 |
| ▸ | LPO | P22079 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.32 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.32 |
| ▸ | TYMP | P19971 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Uracil SCHEMBL28120281 | 0.92 | TP53 (0.83) | TP53MMP2CRBNLPOPTGS1 | |
| Thiouracil SCHEMBL9172 | 0.87 | — | — | |
| Thiouracil SCHEMBL27922231 | 0.85 | — | — | |
| Thiouracil SCHEMBL30091289 | 0.85 | — | — | |
| SCHEMBL26167 | 0.85 | — | — | |
| Thiouracil SCHEMBL28319210 | 0.83 | CRBN (0.56) | TP53MMP2CRBN | |
| Thiouracil SCHEMBL7804101 | 0.82 | TP53 (0.79) | TP53MMP2CRBNLPOPTGS1 | |
| Uracil SCHEMBL28946101 | 0.78 | CRBN (0.90) | TP53MMP2CRBNSMN1; SMN2TYMP | |
| Uracil SCHEMBL8235 | 0.78 | — | — | |
| Uracil SCHEMBL5089507 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11624093-B2 | Tumor suppressor and oncogene biomarkers predictive of anti-immune checkpoint inhibitor response | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-04-11 | — | — | US | disclosed |
| US-20170130271-A1 | TUMOR SUPPRESSOR AND ONCOGENE BIOMARKERS PREDICTIVE OF ANTI-IMMUNE CHECKPOINT INHIBITOR RESPONSE | CHILDREN'S MEDICAL CENTER CORPORATION | 2017-05-11 | — | — | US | disclosed |