SCHEMBL188178

SCHEMBL188178

CC(C)CC(N)(C(=O)O)C(F)(F)F

nearest known ligand 0.41

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
GRM2 Q14416 1/20 0.41
GRM3 Q14832 1/20 0.41
SLC7A5 Q01650 1/20 0.32
ARG1 P05089 1/20 0.31
ARG2 P78540 1/20 0.31
ODC1 P11926 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2D6 P10635 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL188179 1.00 GRM2 (0.41) GRM2GRM3SLC7A5ARG1ARG2
SCHEMBL5704696 1.00 GRM2 (0.41) GRM2GRM3SLC7A5ARG1ARG2
SCHEMBL4314004 0.77 GRM2 (0.43) GRM2GRM3SLC7A5ARG1ARG2
SCHEMBL1629778 0.75 MEN1 (0.40) GRM2GRM3ARG1ARG2ODC1
SCHEMBL11208132 0.74 GABRP (0.42) ARG1ARG2ODC1
SCHEMBL10021004 0.72 GRM2 (0.37) GRM2GRM3SLC7A5CYP2D6
SCHEMBL21821202 0.72 GRM2 (0.46) GRM2GRM3SLC7A5ARG1ARG2
SCHEMBL497762 0.72 GRM2 (0.46) GRM2GRM3SLC7A5ARG1ARG2
SCHEMBL21199502 0.71 MEN1 (0.38) ARG1ARG2ODC1CYP1A2
SCHEMBL5704692 0.71 MEN1 (0.38) ARG1ARG2ODC1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4687443-A1 METHOD FOR FUNCTIONALISING A SOLID SUBSTRATE WITH A PEPTIDE CONJUGATE Genepep (FR) 2026-02-11 EP disclosed
WO-2024208878-A1 METHOD FOR FUNCTIONALISING A SOLID SUBSTRATE WITH A PEPTIDE CONJUGATE GENEPEP (FR) 2024-10-10 WO disclosed
US-20230414702-A1 COMPOUNDS AND PHARMACEUTICAL USE THEREOF IN THE TREATMENT OF CANCER PEPKON SAS (FR) 2023-12-28 US disclosed
US-11759496-B2 Compounds and pharmaceutical use thereof in the treatment of cancer Karoyan, Philippe (FR) 2023-09-19 US disclosed
EP-3454879-B1 NEW COMPOUNDS AND PHARMACEUTICAL USE THEREOF IN THE TREATMENT OF CANCER INST NAT SANTE RECH MED (FR) 2021-12-22 EP disclosed
US-20190144501-A1 NEW COMPOUNDS AND PHARMACEUTICAL USE THEREOF IN THE TREATMENT OF CANCER PEPKON SAS (FR) 2019-05-16 US disclosed
EP-3454879-A1 NEW COMPOUNDS AND PHARMACEUTICAL USE THEREOF IN THE TREATMENT OF CANCER INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2019-03-20 EP disclosed
EP-3220957-B1 CONJUGATED MOLECULES COMPRISING A PEPTIDE DERIVED FROM THE CD4 RECEPTOR COUPLED TO AN ANIONIC POLYPEPTIDE FOR THE TREATMENT OF AIDS PASTEUR INSTITUT (FR) 2018-11-07 EP disclosed
EP-2448956-B1 SOLID PHASE PEPTIDE SYNTHESIS OF PEPTIDE ALCOHOLS CENTRE NAT RECH SCIENT (FR) 2018-05-16 EP disclosed
US-9907860-B2 Conjugated molecules comprising a peptide derived from the CD4 receptor coupled to an anionic polypeptide for the treatment of AIDS INSTITUT PASTEUR (FR) 2018-03-06 US disclosed
EP-1863832-B1 AGE INHIBITORS CENTRE NAT RECH SCIENT (FR) 2012-01-04 EP disclosed
US-20110152464-A1 PIPECOLIC LINKER AND ITS USE FOR CHEMISTRY ON SOLID SUPPORT UNIVERSITE DE MONTPELLIER I (FR) 2011-06-23 US disclosed
EP-2321277-A1 PIPECOLIC LINKER AND ITS USE FOR CHEMISTRY ON SOLID SUPPORT Centre National de la Recherche Scientifique - CNRS (FR) 2011-05-18 EP disclosed
WO-2011000848-A1 SOLID PHASE PEPTIDE SYNTHESIS OF PEPTIDE ALCOHOLS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 2011-01-06 WO disclosed
EP-2270025-A1 Solid phase peptide synthesis of peptide alcohols Centre National pour la Recherche Scientifique (CNRS) (FR) 2011-01-05 EP disclosed
WO-2010023295-A1 PIPECOLIC LINKER AND ITS USE FOR CHEMISTRY ON SOLID SUPPORT CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 2010-03-04 WO disclosed
US-20080249030-A1 Age Inhibitors CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2008-10-09 US disclosed
CN-101268093-A Age inhibitors PHARMAMENS (FR) 2008-09-17 CN disclosed
EP-1863832-A1 AGE INHIBITORS Pharmamens (FR) 2007-12-12 EP disclosed
WO-2006103274-A1 AGE INHIBITORS PHARMAMENS (FR) 2006-10-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190144501-A1 NEW COMPOUNDS AND PHARMACEUTICAL USE THEREOF IN THE TREATMENT OF CANCER VIP, RNASE1, ABCB11 GRM2 4742/4885GRM3 4083/4885SLC7A5 119/4885
US-20110152464-A1 PIPECOLIC LINKER AND ITS USE FOR CHEMISTRY ON SOLID SUPPORT PRRC2C, VIP, PRRC2A GRM2 4734/4885GRM3 4617/4885SLC7A5 32/4885
US-11759496-B2 Compounds and pharmaceutical use thereof in the treatment of cancer VIP, RNASE1, ABCB11 GRM2 4730/4885GRM3 3963/4885SLC7A5 199/4885
US-20230414702-A1 COMPOUNDS AND PHARMACEUTICAL USE THEREOF IN THE TREATMENT OF CANCER VIP, RNASE1, ABCB11 GRM2 4730/4885GRM3 3963/4885SLC7A5 199/4885
US-20080249030-A1 Age Inhibitors CFH, XPA, XPNPEP1 GRM2 4789/4885GRM3 3469/4885SLC7A5 2318/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.