Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 9/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18842295 | 0.83 | ALDH1A1 (0.64) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL18831902 | 0.81 | CTSB (0.36) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL18842299 | 0.78 | ALDH1A1 (0.57) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL1527207 | 0.75 | SIRT6 (0.80) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL29537193 | 0.75 | SIRT6 (0.80) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL29753282 | 0.74 | ALDH1A1 (0.78) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL20472814 | 0.74 | ALDH1A1 (0.49) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL2033139 | 0.74 | ALDH1A1 (0.69) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL3716926 | 0.74 | ALDH1A1 (0.60) | ALDH1A1LMNASIRT6MAPTKMT2A | |
| SCHEMBL2763067 | 0.74 | ALDH1A1 (0.60) | ALDH1A1LMNASIRT6MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3165530-A1 | SPIROCYCLIC ARYL PHOSPHORUS OXIDE AND ARYL PHOSPHORUS SULFIDE | Qilu Pharmaceutical Co., Ltd (CN) | 2017-05-10 | — | — | EP | disclosed |