Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 5/20 | 0.79 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18832654 | 0.88 | LPAR1 (0.63) | LPAR1NPC1RAB9ANOX1 | |
| SCHEMBL1561172 | 0.88 | LPAR1 (1.00) | LPAR1GPR132 | |
| SCHEMBL18832675 | 0.88 | LPAR1 (0.61) | LPAR1GPR132NPC1RAB9ASIRT2 | |
| SCHEMBL18832662 | 0.87 | LPAR1 (0.60) | LPAR1GPR132NPC1RAB9ASIRT2 | |
| SCHEMBL18832661 | 0.87 | LPAR1 (0.60) | LPAR1MAPT | |
| SCHEMBL18832658 | 0.86 | LPAR1 (0.58) | LPAR1GPR132NPC1RAB9ANR1H4 | |
| SCHEMBL18832664 | 0.86 | LPAR1 (0.58) | LPAR1GPR132NPC1RAB9ASIRT2 | |
| SCHEMBL1561438 | 0.85 | LPAR1 (0.85) | LPAR1GPR132NPC1RAB9ASIRT2 | |
| SCHEMBL18832656 | 0.82 | LPAR1 (0.54) | LPAR1GPR132SIRT2F10NOX1 | |
| SCHEMBL18832678 | 0.82 | LPAR1 (0.63) | LPAR1NPC1RAB9ANOX1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2303270-B1 | ACYLAMINO-SUBSTITUTED FUSED CYCLOPENTANECARBOXYLIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI SA (FR) | 2017-05-17 | — | — | EP | claimed |