Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
| ▸ | CASR | P41180 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18834648 | 0.80 | PDE5A (0.37) | PDE5AHPGDTSHRCASR | |
| SCHEMBL18834032 | 0.77 | MDM2 (0.36) | MDM2CHRM4MCHR1HPGDTSHR | |
| SCHEMBL20432149 | 0.72 | CASR (0.33) | MDM2MCHR1HPGDTSHRHSD17B10 | |
| SCHEMBL18834613 | 0.72 | SMN1; SMN2 (0.41) | PDE5AMDM2HPGDMEN1KMT2A | |
| SCHEMBL18835220 | 0.70 | DPP4 (0.37) | MDM2DPP4MEN1KMT2ANPSR1 | |
| SCHEMBL19375084 | 0.68 | MDM2 (0.34) | PDE5AMDM2CHRM4MCHR1HPGD | |
| SCHEMBL16028050 | 0.67 | TRPC4 (0.52) | HPGDTSHRMEN1KMT2ANPSR1 | |
| SCHEMBL18833700 | 0.64 | MDM2 (0.37) | MDM2CHRM4DPP4 | |
| SCHEMBL16076079 | 0.63 | TRPC4 (0.52) | HPGDTSHRKMT2ANPSR1 | |
| SCHEMBL18833781 | 0.63 | TSHR (0.37) | PDE5AHPGDTSHRCASRPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-09-20 | — | — | EP | disclosed |
| EP-2970303-B1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-05-10 | — | — | EP | disclosed |