Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19374868 | 0.82 | P2RX3 (0.36) | TSHRADORA3BRD4LMNAS1PR2 | |
| SCHEMBL18834275 | 0.81 | TP53 (0.37) | TSHRADORA3PDE5APDE4APDE4B | |
| SCHEMBL18834221 | 0.80 | P2RX3 (0.40) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL19375602 | 0.78 | ADORA3 (0.43) | TSHRADORA3PPARGSMN1; SMN2 | |
| SCHEMBL8007895 | 0.74 | PDE5A (0.39) | TSHRPDE5ABRD4HPGDS1PR2 | |
| SCHEMBL18834648 | 0.74 | PDE5A (0.37) | TSHRADORA3PDE5APDE4APDE4B | |
| SCHEMBL18833638 | 0.74 | USP1 (0.38) | LMNASMN1; SMN2 | |
| SCHEMBL22111414 | 0.73 | PDE5A (0.33) | ADORA3PDE5APDE4APDE4BPDE4C | |
| SCHEMBL18834562 | 0.71 | P2RX7 (0.40) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18834247 | 0.71 | P2RX3 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-05-10 | — | — | EP | disclosed |