Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 8/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | CASR | P41180 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18834613 | 0.80 | SMN1; SMN2 (0.41) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18833947 | 0.80 | PDE5A (0.37) | PDE5ACASRTSHRHPGD | |
| SCHEMBL18835220 | 0.80 | DPP4 (0.37) | LMNASMN1; SMN2 | |
| SCHEMBL18833781 | 0.74 | TSHR (0.37) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL20432149 | 0.71 | CASR (0.33) | CASRCSNK2A2CSNK2BCSNK2A1ABCG2 | |
| SCHEMBL18834032 | 0.71 | MDM2 (0.36) | CASRCSNK2A2CSNK2BCSNK2A1ABCG2 | |
| SCHEMBL18833700 | 0.68 | MDM2 (0.37) | CSNK2A2CSNK2BCSNK2A1ABCG2 | |
| SCHEMBL19375362 | 0.67 | MDM2 (0.32) | CSNK2A2CSNK2BCSNK2A1ABCG2 | |
| SCHEMBL16027909 | 0.65 | BRAF (0.56) | TSHRADORA3LMNAHPGDSMN1; SMN2 | |
| SCHEMBL18834975 | 0.64 | KDM4E (0.39) | PDE5APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-09-20 | — | — | EP | disclosed |
| EP-2970303-B1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-05-10 | — | — | EP | disclosed |