Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | GALR3 | O60755 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23373796 | 0.69 | ALDH1A1 (0.37) | PDE4AADORA2AADORA2BPDE4BPDE4C | |
| SCHEMBL18834584 | 0.64 | TRPC5 (0.50) | — | |
| SCHEMBL16027932 | 0.63 | CYP1A2 (0.44) | HTTL3MBTL1LMNASMN1; SMN2PDE4A | |
| SCHEMBL15215819 | 0.62 | CYP3A4 (0.64) | HTTLMNASMN1; SMN2PDE4AADORA2A | |
| SCHEMBL11034051 | 0.62 | CYP3A4 (0.64) | HTTLMNASMN1; SMN2PDE4AADORA2A | |
| SCHEMBL19375505 | 0.61 | PDE4A (0.33) | LMNAPDE4AADORA2BPDE4BPDE4C | |
| SCHEMBL16199490 | 0.61 | ADORA2B (0.35) | ADORA2BALDH1A1 | |
| SCHEMBL18834424 | 0.61 | ADORA2B (0.39) | TSHRPDE4AADORA2AADORA2BPDE4B | |
| SCHEMBL398824 | 0.61 | PDE4A (0.42) | HTTL3MBTL1LMNATSHRRAB9A | |
| SCHEMBL18833894 | 0.60 | KDM4E (0.46) | L3MBTL1MAPK1LMNAPDE4AADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-09-20 | — | — | EP | disclosed |
| EP-2970303-B1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-05-10 | — | — | EP | disclosed |