Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GNRHR | P30968 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21499684 | 0.83 | P2RX3 (0.44) | PDE5AP2RX3 | |
| SCHEMBL19505233 | 0.82 | P2RX3 (0.45) | PDE5AP2RX3 | |
| SCHEMBL19505418 | 0.82 | PDE5A (0.42) | PDE5AP2RX3TSHR | |
| SCHEMBL19374881 | 0.80 | P2RX3 (0.44) | PDE5AP2RX3 | |
| SCHEMBL21499644 | 0.80 | PDE5A (0.40) | PDE5AP2RX3TSHRGRIN1GRIN2B | |
| SCHEMBL20432432 | 0.79 | PDE5A (0.37) | PDE5AP2RX3TSHR | |
| SCHEMBL21499680 | 0.76 | P2RX3 (0.39) | MAPTP2RX3TSHR | |
| SCHEMBL19375398 | 0.76 | P2RX3 (0.38) | PDE5AMAPTP2RX3TSHR | |
| SCHEMBL19375436 | 0.75 | P2RX7 (0.35) | PDE5AP2RX3TSHRGRIN1GRIN2B | |
| SCHEMBL20432022 | 0.75 | TRPC4 (0.42) | P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-09-20 | — | — | EP | disclosed |
| EP-2970303-B1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-05-10 | — | — | EP | disclosed |