Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 14/20 | 0.47 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.40 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | CTSA | P10619 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19505043 | 0.89 | TRPC5 (0.37) | TRPC5TRPC4P2RX3 | |
| SCHEMBL21499708 | 0.87 | COMT (0.33) | TRPC5P2RX3 | |
| SCHEMBL18834622 | 0.85 | P2RX3 (0.35) | TRPC5P2RX3 | |
| SCHEMBL20432382 | 0.84 | TRPC5 (0.40) | TRPC5TRPC1TRPC4P2RX3 | |
| SCHEMBL21499676 | 0.81 | TRPC5 (0.48) | TRPC5TRPC1TRPC4P2RX3 | |
| SCHEMBL19505365 | 0.80 | TRPC5 (0.42) | TRPC5TRPC1TRPC4P2RX3 | |
| SCHEMBL18834470 | 0.80 | TRPC5 (0.35) | TRPC5P2RX3 | |
| SCHEMBL18834542 | 0.79 | P2RX3 (0.31) | P2RX3 | |
| SCHEMBL21499640 | 0.78 | MDM2 (0.38) | TRPC5P2RX3 | |
| SCHEMBL19505349 | 0.78 | TRPC5 (0.48) | TRPC5TRPC1TRPC4P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-09-20 | — | — | EP | disclosed |
| EP-2970303-B1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-05-10 | — | — | EP | disclosed |