Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 5/20 | 0.35 |
| ▸ | TRPC5 | Q9UL62 | 3/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.30 |
| ▸ | CDK8 | P49336 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19505043 | 0.91 | TRPC5 (0.37) | P2RX3TRPC5CCNCCDK8 | |
| SCHEMBL21499708 | 0.90 | COMT (0.33) | P2RX3TRPC5CCNCCDK8 | |
| SCHEMBL18835240 | 0.85 | TRPC5 (0.47) | P2RX3TRPC5 | |
| SCHEMBL19375051 | 0.84 | MDM2 (0.38) | P2RX3 | |
| SCHEMBL18834470 | 0.82 | TRPC5 (0.35) | P2RX3TRPC5 | |
| SCHEMBL18834542 | 0.81 | P2RX3 (0.31) | P2RX3 | |
| SCHEMBL19375606 | 0.76 | P2RX3 (0.37) | P2RX3TRPC5 | |
| SCHEMBL16027648 | 0.76 | TRPC5 (0.48) | TRPC5 | |
| SCHEMBL30171300 | 0.76 | TRPC5 (0.48) | TRPC5 | |
| SCHEMBL21316348 | 0.75 | ALDH1A1 (0.40) | TRPC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-09-20 | — | — | EP | disclosed |
| EP-2970303-B1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-05-10 | — | — | EP | disclosed |