Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | BPTF | Q12830 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | DHPS | P49366 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | NEK2 | P51955 | 2/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9134895 | 0.90 | TMEM97 (0.49) | KDM4ECNR2TMEM97SIGMAR1BPTF | |
| SCHEMBL5204968 | 0.84 | TUBB1 (0.46) | TUBB1BPTFDHPSBRD4 | |
| SCHEMBL7828568 | 0.82 | PKM (0.49) | KDM4EALDH1A1HPGDPKMLCK | |
| SCHEMBL18031322 | 0.76 | TPMT (0.57) | CNR2TUBB1BPTFALDH1A1PKM | |
| SCHEMBL10370336 | 0.74 | TPMT (0.51) | KDM4EALDH1A1HPGDPKMLCK | |
| SCHEMBL1889122 | 0.72 | KDM4E (0.40) | KDM4ETMEM97SIGMAR1ALDH1A1HPGD | |
| SCHEMBL8961617 | 0.72 | BPTF (0.61) | KDM4EBPTFALDH1A1 | |
| SCHEMBL7122419 | 0.72 | TUBB1 (0.49) | KDM4ETUBB1BPTFALDH1A1HPGD | |
| SCHEMBL15845864 | 0.71 | ALDH1A1 (0.50) | KDM4EALDH1A1HPGDPKMLCK | |
| SCHEMBL23060136 | 0.71 | MAOB (0.39) | KDM4ECNR2BPTFALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193360-B2 | Radiolabelled fluorobenzamide analogues, their synthesis and use in diagnostic imaging | WASHINGTON UNIVERSITY (US) | 2012-06-05 | — | — | US | disclosed |
| US-8193360-B2 | Radiolabelled fluorobenzamide analogues, their synthesis and use in diagnostic imaging | WASHINGTON UNIVERSITY (US) | 2012-06-05 | — | — | US | disclosed |
| US-20110230662-A1 | RADIOLABELLED FLUOROBENZAMIDE ANALOGUES, THEIR SYNTHESIS AND USE IN DIAGNOSTIC IMAGING | WASHINGTON UNIVERSITY (US) | 2011-09-22 | — | — | US | disclosed |
| US-20110230662-A1 | RADIOLABELLED FLUOROBENZAMIDE ANALOGUES, THEIR SYNTHESIS AND USE IN DIAGNOSTIC IMAGING | WASHINGTON UNIVERSITY (US) | 2011-09-22 | — | — | US | disclosed |
| US-7947838-B2 | Radiolabelled benzamide analogues, their synthesis and use in diagnostic imaging | WASHINGTON UNIVERSITY (US) | 2011-05-24 | — | — | US | disclosed |
| US-7947838-B2 | Radiolabelled benzamide analogues, their synthesis and use in diagnostic imaging | WASHINGTON UNIVERSITY (US) | 2011-05-24 | — | — | US | disclosed |
| US-20100150836-A1 | RADIOLABELLED BENZAMIDE ANALOGUES, THEIR SYNTHESIS AND USE IN DIAGNOSTIC IMAGING | WASHINGTON UNIVERSITY (US) | 2010-06-17 | — | — | US | disclosed |
| US-20100150836-A1 | RADIOLABELLED BENZAMIDE ANALOGUES, THEIR SYNTHESIS AND USE IN DIAGNOSTIC IMAGING | WASHINGTON UNIVERSITY (US) | 2010-06-17 | — | — | US | disclosed |
| EP-2164327-A2 | RADIOLABELLED FLUOROBENZAMIDE ANALOGUES, THEIR SYNTHESIS AND USE IN DIAGNOSTIC IMAGING | WASHINGTON UNIVERSITY (US) | 2010-03-24 | — | — | EP | disclosed |
| US-7659400-B2 | Radiolabelled benzamide analogues, their synthesis and use in diagnostic imaging | WASHINGTON UNIVERSITY (US) | 2010-02-09 | — | — | US | disclosed |
| WO-2009025914-A2 | RADIOLABELLED FLUOROBENZAMIDE ANALOGUES, THEIR SYNTHESIS AND USE IN DIAGNOSTIC IMAGING | WASHINGTON UNIVERSITY (US) | 2009-02-26 | — | — | WO | disclosed |
| US-20080107599-A1 | RADIOLABELLED BENZAMIDE ANALOGUES, THEIR SYNTHESIS AND USE IN DIAGNOSTIC IMAGING | WASHINGTON UNIVERSITY OF ST. LOUIS | 2008-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080107599-A1 | RADIOLABELLED BENZAMIDE ANALOGUES, THEIR SYNTHESIS AND USE IN DIAGNOSTIC IMAGING | TMEM97, SIGMAR1, SFN | KDM4E 4331/4885CNR2 46/4885TUBB1 510/4885 |
| US-20100150836-A1 | RADIOLABELLED BENZAMIDE ANALOGUES, THEIR SYNTHESIS AND USE IN DIAGNOSTIC IMAGING | TMEM97, SIGMAR1, SFN | KDM4E 4331/4885CNR2 46/4885TUBB1 510/4885 |
| US-20110230662-A1 | RADIOLABELLED FLUOROBENZAMIDE ANALOGUES, THEIR SYNTHESIS AND USE IN DIAGNOSTIC IMAGING | TMEM97, SIGMAR1, SFN | KDM4E 4470/4885CNR2 52/4885TUBB1 353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.