SFN — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL7709781	0.55	2/20
SCHEMBL7563980	0.45	2/20
SCHEMBL7428892	0.41	2/20
Hydrochloric Acid (SCHEMBL6365976)	0.40	2/20
SCHEMBL31273363	0.63	1/20
SCHEMBL31272518	0.62	1/20
SCHEMBL31306466	0.56	1/20
SCHEMBL2008072	0.55	1/20
SCHEMBL2557848	0.54	1/20
SCHEMBL31272242	0.54	1/20
SCHEMBL9722697	0.53	1/20
SCHEMBL4002979	0.52	1/20
SCHEMBL4905485	0.52	1/20
SCHEMBL6356182	0.52	1/20
SCHEMBL31470148	0.52	1/20
SCHEMBL4010958	0.51	1/20
SCHEMBL9621530	0.51	1/20
SCHEMBL28815524	0.51	1/20
SCHEMBL28833417	0.51	1/20
SCHEMBL6355103	0.50	1/20

Clinical trials — most relevant to SFN by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Efficacy of Ketamine Mouthwash in the Management of Oral and Pharyngeal Toxicity Associated With Head and Neck Chemoradiotherapy: A Phase 2, Simon 2-stage Trial	PHASE2	WITHDRAWN
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
A Multicenter Study of NAP (AL-108) in Schizophrenia	PHASE2	COMPLETED
Effects of Lovaza on Lipoprotein Composition and Function in Mild Hypertriglyceridemia	PHASE1/PHASE2	COMPLETED
Safety and Impact of Dasatinib on Viral Persistence and Inflammation in People With HIV Under Antiretroviral Treatment	PHASE2	COMPLETED
Study of Decitabine in Combination With Sequential Rapamycin or Ribavirin in High Risk AML Patients	PHASE1/PHASE2	COMPLETED
Sulforaphane in a New Jersey (NJ) Population of Individuals With Autism	PHASE2	ACTIVE_NOT_RECRUITING
Safety and Pharmacology of SNX-5422 Plus Carboplatin and Paclitaxel in Subjects With Solid Tumors	PHASE1	COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
Study of Oral CNF2024 (BIIB021) in Advanced Solid Tumors	PHASE1	COMPLETED
Nebulised BromAc in Healthy Volunteers	PHASE1	COMPLETED
Phase I Study of SC-43 Oral Solution in Subjects With Refractory Solid Tumors	PHASE1	WITHDRAWN
A Phase I Trial of Enzastaurin (LY317615) in Combination With Carboplatin in Adults With Recurrent Gliomas	PHASE1	COMPLETED
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia	nan	NOT_YET_RECRUITING
Semen Analysis Changes in Covid-19 Positivepatients	nan	COMPLETED
Short-Term Broccoli Supplementation and Acute Oxidative Stress Recovery	nan	COMPLETED
Evaluation of the Predictive Effect of Inflammatory Markers in MI Patients	nan	UNKNOWN
Quantification of GADD34 Expression in RA	nan	COMPLETED
Immune Cell Response to Stimuli	nan	RECRUITING
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy	nan	COMPLETED
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus	nan	COMPLETED
Vulvodynia: Identification of Potential Relevant Biomarkers	nan	COMPLETED
Disease Biosignatures in ALS/FTD Spectrum: New Impactful Biological Perspectives Beyond Clinical Approaches	nan	RECRUITING
Recombinant Interferon Alfa-2b in Treating Patients With Melanoma	nan	COMPLETED
Impacts of Omega-3-PUFA Enriched Chicken-meat and Eggs in Healthy Humans	nan	COMPLETED
Association Between Intakes of Protein, Calcium and Milk With Gene Expression and Linear Growth of School Aged Children	nan	COMPLETED
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Selenium Levels in Patients With Abdominal Aneurysm	nan	ACTIVE_NOT_RECRUITING
Role of Sorcin and Annexin A3 in Breast Cancer Patients	nan	UNKNOWN
Therapeutic Effect of Sodium Selenite on Oxidative Stress in Patients With Severe Sepsis	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SFN binder may also engage these)

Protein	Name	Similarity
Q0VC36	—	1.000	Q0VC36 →
Q1HR36	—	1.000	Q1HR36 →
P35213	—	1.000	P35213 →
P68250	—	1.000	P68250 →
Q96299	—	1.000	Q96299 →
P41932	—	1.000	P41932 →
Q5PRD0	—	0.999	Q5PRD0 →
A4K2U9	—	0.999	A4K2U9 →
Q4R572	—	0.999	Q4R572 →
YWHAB	14-3-3 protein beta/alpha	0.999	landscape →
Q7T356	—	0.999	Q7T356 →
O70456	—	0.999	O70456 →
P46077	—	0.999	P46077 →
P46266	—	0.999	P46266 →
Q9CQV8	—	0.998	Q9CQV8 →
P93342	—	0.998	P93342 →
P63103	—	0.998	P63103 →
Q6NRY9	—	0.998	Q6NRY9 →
P63101	—	0.998	P63101 →
P61983	—	0.998	P61983 →
O77642	—	0.998	O77642 →
P62262	—	0.997	P62262 →
Q5ZMT0	—	0.997	Q5ZMT0 →
Q6P4Z5	—	0.997	Q6P4Z5 →
P93259	—	0.997	P93259 →
Q5F3W6	—	0.997	Q5F3W6 →
Q43643	—	0.997	Q43643 →
Q6EUP4	—	0.997	Q6EUP4 →
Q8MUA4	—	0.996	Q8MUA4 →
P93213	—	0.996	P93213 →