SCHEMBL1884093

SCHEMBL1884093

O=C1c2ccccc2C(=O)c2c(NCC(O)CO)cccc21

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.56
KMT2A Q03164 5/20 0.56
MAPT P10636 4/20 0.56
L3MBTL1 Q9Y468 3/20 0.56
POLB P06746 3/20 0.56
ALDH1A1 P00352 3/20 0.56
EGFR P00533 2/20 0.56
MAPK1 P28482 2/20 0.56
SMN1; SMN2 Q16637 2/20 0.56
BLM P54132 2/20 0.56
RAD52 P43351 2/20 0.56
LMNA P02545 1/20 0.56
HTT P42858 1/20 0.56
RECQL P46063 1/20 0.56
NPSR1 Q6W5P4 1/20 0.56
PABPC1 P11940 2/20 0.53
RAB9A P51151 2/20 0.53
TDP1 Q9NUW8 1/20 0.53
MAOA P21397 1/20 0.51
NSD2 O96028 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL125775 0.89 TOP2B (0.56) MEN1KMT2AMAPTL3MBTL1POLB
SCHEMBL6002443 0.84 MAPT (0.47) MEN1KMT2AMAPTL3MBTL1POLB
SCHEMBL8356756 0.83 MAPT (0.58) MEN1KMT2AMAPTL3MBTL1POLB
SCHEMBL20334299 0.82 MEN1 (0.54) MEN1KMT2AMAPTL3MBTL1POLB
SCHEMBL25720006 0.82 BCL2 (0.52) MEN1KMT2AMAPTL3MBTL1POLB
SCHEMBL20333920 0.82 TOP2B (0.50) MEN1KMT2AMAPTL3MBTL1POLB
SCHEMBL9384951 0.82 TOP2B (0.65) MEN1KMT2AMAPTL3MBTL1POLB
SCHEMBL20334218 0.82 TOP2B (0.50) MEN1KMT2AMAPTL3MBTL1POLB
SCHEMBL20333928 0.82 MAPT (0.50) MEN1KMT2AMAPTL3MBTL1POLB
SCHEMBL4732627 0.80 MEN1 (0.72) MEN1KMT2AMAPTL3MBTL1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014060407-A2 AQUEOUS WAX DISPERSIONS FOR ALTERING THE COLOR OF KERATINOUS SUBSTRATES L'OREAL (FR) 2014-04-24 WO disclosed
EP-2229140-B1 AZOMETHINE DIRECT DYES OR REDUCED PRECURSORS OF THESE DYES OBTAINED FROM 2-CHLORO-3-AMINO-6-METHYLPHENOL, AND HAIR DYEING METHOD STARTING FROM THESE DYES AND PRECURSORS OREAL (FR) 2011-08-03 EP disclosed
US-7935154-B2 Process for lightening or lightening direct dyeing or oxidation dyeing in the presence of at least one organic amine and at least one inorganic base, and device therefor L'OREAL S.A. (FR) 2011-05-03 US disclosed
WO-2010142776-A1 N-OXIDIZED AZOMETHINE DIRECT DYES OR REDUCED PRECURSORS OF THESE DYES OBTAINED FROM SECONDARY, N-ALKYLAMINATED PARA-PHENYLENEDIAMINES, METHOD OF HAIR DYEING USING THESE DYES L'OREAL (FR) 2010-12-16 WO disclosed
WO-2010142777-A1 AZOMETHINE DIRECT DYES OR REDUCED PRECURSORS OF THESE DYES OBTAINED FROM SECONDARY, N-ALKYLAMINATED PARA-PHENYLENEDIAMINES, METHOD OF HAIR DYEING USING THESE DYES L'OREAL (FR) 2010-12-16 WO disclosed
EP-2234587-A2 COMPOSITION COMPRISING AN ALKANOLAMINE, AN AMINO ACID AND AN ASSOCIATIVE POLYMER L'Oréal (FR) 2010-10-06 EP disclosed
US-20100175705-A1 PROCESS FOR LIGHTENING OR LIGHTENING DIRECT DYEING OR OXIDATION DYEING IN THE PRESENCE OF AT LEAST ONE ORGANIC AMINE AND AT LEAST ONE INORGANIC BASE, AND DEVICE THEREFOR L'OREAL S.A. (FR) 2010-07-15 US disclosed
EP-2201070-A2 AZO QUINOLINIUM COMPOUNDS COMPRISING A DISULPHIDE/THIOL UNIT, COMPOSITIONS CONTAINING SAME, PROCESS FOR DYEING KERATIN FIBRES AND DEVICE L'Oreal (FR) 2010-06-30 EP disclosed
EP-2170260-A1 AZO DERIVATIVES CONTAINING A PYRAZOLINONE UNIT FOR DYEING KERATIN FIBRES L'Oreal (FR) 2010-04-07 EP disclosed
US-7608115-B2 Process for treating keratin fibres by applying heat L'OREAL S.A. (FR) 2009-10-27 US disclosed
EP-1819682-A1 SYMMETRICAL CATIONIC TETRAAZO COMPOUNDS, FOR DYEING KERATIN FIBRES L'Oréal (FR) 2007-08-22 EP disclosed
EP-1819779-A2 PARTICULAR DISSYMMETRICAL CATIONIC POLYAZO COMPOUNDS, COMPOSITIONS COMPRISING THEM AS DIRECT DYE, PROCESS FOR DYEING KERATIN FIBRES AND DEVICE THEREFOR L'Oréal (FR) 2007-08-22 EP disclosed
US-20070174974-A1 Process for treating keratin fibres by applying heat L'OREAL S.A. (FR) 2007-08-02 US disclosed
WO-2006106000-A1 AQUEOUS COMPOSITION COMPRISING HYDROGEN PEROXIDE AND INERT PARTICLES L'ORÉAL (FR) 2006-10-12 WO disclosed
WO-2006097360-A1 PROCESS FOR DYEING THE HAIR USING AN ANIONIC COLOURED POLYMER L'OREAL (FR) 2006-09-21 WO disclosed
WO-2006056488-A1 SYMMETRICAL CATIONIC TETRAAZO COMPOUNDS, FOR DYEING KERATIN FIBRES L'OREAL (FR) 2006-06-01 WO disclosed
WO-2006056489-A2 PARTICULAR DISSYMMETRICAL CATIONIC POLYAZO COMPOUNDS, COMPOSITIONS COMPRISING THEM AS DIRECT DYE, PROCESS FOR DYEING KERATIN FIBRES AND DEVICE THEREFOR L'OREAL (FR) 2006-06-01 WO disclosed
EP-1631241-A1 PROCESS FOR TREATING KERATIN FIBRES BY APPLYING HEAT L'OREAL (FR) 2006-03-08 EP disclosed
US-7001436-B2 Dyeing composition for keratinous fibres comprising a particular dicationic diazo dye L'OREAL S.A. (FR) 2006-02-21 US disclosed
WO-2004098550-A1 PROCESS FOR TREATING KERATIN FIBRES BY APPLYING HEAT L'OREAL (FR) 2004-11-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100175705-A1 PROCESS FOR LIGHTENING OR LIGHTENING DIRECT DYEING OR OXIDATION DYEING IN THE PRESENCE OF AT LEAST ONE ORGANIC AMINE AND AT LEAST ONE INORGANIC BASE, AND DEVICE THEREFOR KRT18, HADHB, CUTA MEN1 1991/4885KMT2A 2539/4885MAPT 1767/4885
US-20070174974-A1 Process for treating keratin fibres by applying heat KRT18, FECH, HSPD1 MEN1 4028/4885KMT2A 1383/4885MAPT 367/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.