Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | KLK7 | P49862 | 6/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PAM | P19021 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18848357 | 1.00 | TSHR (0.56) | TSHRKLK7SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL18848282 | 1.00 | TSHR (0.56) | TSHRKLK7SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL18848346 | 0.94 | TSHR (0.50) | TSHRKLK7SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL18848284 | 0.94 | TSHR (0.50) | TSHRKLK7SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL18848247 | 0.94 | TSHR (0.50) | TSHRKLK7SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL18848274 | 0.80 | TSHR (0.47) | TSHRALDH1A1SMN1; SMN2ADRB2ADRB1 | |
| SCHEMBL18848251 | 0.80 | TSHR (0.47) | TSHRALDH1A1SMN1; SMN2ADRB2ADRB1 | |
| SCHEMBL18848364 | 0.80 | TSHR (0.47) | TSHRALDH1A1SMN1; SMN2ADRB2ADRB1 | |
| SCHEMBL18848272 | 0.77 | ALDH1A1 (0.53) | TSHRSLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL18848358 | 0.76 | CHRNB2 (0.32) | TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9738620-B2 | Trientine prodrugs, pharmaceutical compositions thereof, and methods of use | Nguyen, Mark Quang (US) | 2017-08-22 | — | — | US | disclosed |
| US-20170129868-A1 | TRIENTINE PRODRUGS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE | Nguyen, Mark Quang (US) | 2017-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170129868-A1 | TRIENTINE PRODRUGS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE | SLC10A1, ABCB11, SLC10A2 | TSHR 2355/4885KLK7 3620/4885SLC6A2 320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.