Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 1/20 | 0.55 |
| ▸ | HPGDS | O60760 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.49 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.48 |
| ▸ | CASR | P41180 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 4/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.46 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16455199 | 0.94 | KMT2A (0.49) | CTSBPIN1CASRNPC1P2RY12 | |
| SCHEMBL18848748 | 0.90 | CTSB (0.58) | CTSBHPGDSHPGDCASRKDM1A | |
| SCHEMBL18848471 | 0.89 | CTSB (0.57) | CTSBHPGDSHPGDCASRKDM1A | |
| SCHEMBL16455182 | 0.88 | KDM1A (0.53) | KDM1AALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL16455072 | 0.87 | KDM1A (0.60) | CTSBHPGDSKDM1AP2RY12KMT2A | |
| SCHEMBL18848749 | 0.86 | KDM1A (0.61) | CTSBHPGDSKDM1A | |
| SCHEMBL18043507 | 0.84 | KMT2A (0.50) | PIN1KDM1ANPC1ALDH1A1MAPT | |
| SCHEMBL16447123 | 0.84 | KMT2A (0.50) | PIN1KDM1ANPC1ALDH1A1MAPT | |
| SCHEMBL16455183 | 0.83 | KDM1A (0.64) | CTSBHPGDSKDM1AP2RY12ALDH1A1 | |
| SCHEMBL18848470 | 0.83 | HPGD (0.47) | HPGDCD274PIN1ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017079753-A1 | LYSINE-SPECIFIC HISTONE DEMETHYLASE AS A NOVEL THERAPEUTIC TARGET IN MYELOPROLIFERATIVE NEOPLASMS | IMAGO BIOSCIENCES, INC. (US) | 2017-05-11 | — | — | WO | disclosed |