Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TOP1 | P11387 | 2/20 | 0.33 |
| ▸ | ARG1 | P05089 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | TOP2A | P11388 | 1/20 | 0.30 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 2/20 | 0.30 |
| ▸ | CA1 | P00915 | 2/20 | 0.30 |
| ▸ | CA2 | P00918 | 2/20 | 0.30 |
| ▸ | CA9 | Q16790 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrimidine SCHEMBL9443953 | 0.84 | GAA (0.35) | GAAGFERAPOBEC3GIDO1MEN1 | |
| SCHEMBL11405325 | 0.79 | ARG1 (0.50) | IDO1TOP1ARG1HDAC6APP | |
| SCHEMBL13537486 | 0.73 | ALDH1A1 (0.48) | GAAGFERIDO1ALDH1A1HSD17B10 | |
| SCHEMBL21026389 | 0.73 | CA2 (0.39) | GAAIDO1ALDH1A1HDAC6MEN1 | |
| SCHEMBL12455883 | 0.73 | HDAC6 (0.34) | HDAC6 | |
| SCHEMBL21160394 | 0.69 | KDM4E (0.59) | ALDH1A1EGFRAPPKDM5ARAB9A | |
| SCHEMBL18716965 | 0.69 | ERN1 (0.53) | — | |
| SCHEMBL28728770 | 0.68 | ALOX15 (0.52) | GAAIDO1ALDH1A1HSD17B10ARG1 | |
| SCHEMBL6653675 | 0.68 | ALDH1A1 (0.50) | GAAALDH1A1HSD17B10EGFRMEN1 | |
| SCHEMBL6762996 | 0.68 | GAA (0.38) | GAAGFERAPOBEC3GIDO1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017079519-A1 | HETEROCYCLIC COMPOUNDS AS PI3K-GAMMA INHIBITORS | INCYTE CORPORATION (US) | 2017-05-11 | — | — | WO | disclosed |