⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17011135 | 0.84 | TSHR (0.40) | — | |
| SCHEMBL17011224 | 0.82 | — | — | |
| SCHEMBL6894109 | 0.78 | PRKCA (0.42) | — | |
| SCHEMBL20260412 | 0.77 | — | — | |
| SCHEMBL14513533 | 0.76 | DGAT1 (0.39) | — | |
| SCHEMBL19359770 | 0.75 | — | — | |
| SCHEMBL20260566 | 0.75 | — | — | |
| SCHEMBL18924861 | 0.74 | CTSK (0.33) | — | |
| SCHEMBL17011227 | 0.72 | MMP8 (0.37) | — | |
| SCHEMBL20697330 | 0.71 | MMP8 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10011569-B2 | Process for synthesizing oxidized lactam compounds | ALKERMES PHARMA IRELAND LIMITED (IE) | 2018-07-03 | — | — | US | disclosed |
| US-20170267639-A1 | Process for Synthesizing Oxidized Lactam Compounds | JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT | 2017-09-21 | — | — | US | disclosed |
| US-9650341-B2 | Process for synthesizing oxidized lactam compounds | ALKERMES PHARMA IRELAND LIMITED (IE) | 2017-05-16 | — | — | US | disclosed |