SCHEMBL188570

SCHEMBL188570

N[C@H](C(=O)O)C(C(F)(F)F)C(F)(F)F

nearest known ligand 0.43

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 1/20 0.43
SLC1A3 P43003 7/20 0.37
SLC1A2 P43004 7/20 0.37
SLC1A1 P43005 6/20 0.37
USP2 O75604 1/20 0.34
SLCO1B1 Q9Y6L6 1/20 0.34
PTGS1 P23219 2/20 0.33
ALDH1A1 P00352 1/20 0.33
MAPT P10636 1/20 0.33
SLC7A11 Q9UPY5 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL188569 1.00 SLC7A5 (0.43) SLC7A5SLC1A3SLC1A2SLC1A1USP2
SCHEMBL18528367 0.78 SLC7A5 (0.43) SLC7A5SLC1A3SLC1A2SLC1A1USP2
SCHEMBL17234503 0.78 SLC7A5 (0.43) SLC7A5SLC1A3SLC1A2SLC1A1USP2
SCHEMBL18528440 0.78 SLC7A5 (0.43) SLC7A5SLC1A3SLC1A2SLC1A1USP2
SCHEMBL17234504 0.78 SLC7A5 (0.43) SLC7A5SLC1A3SLC1A2SLC1A1USP2
SCHEMBL647206 0.76 SLC7A5 (0.42) SLC7A5SLC1A3SLC1A2SLC1A1USP2
SCHEMBL647205 0.76 SLC7A5 (0.42) SLC7A5SLC1A3SLC1A2SLC1A1USP2
SCHEMBL13413615 0.76 SLC7A5 (0.42) SLC7A5SLC1A3SLC1A2SLC1A1USP2
SCHEMBL13413616 0.76 SLC7A5 (0.42) SLC7A5SLC1A3SLC1A2SLC1A1USP2
SCHEMBL13413617 0.76 SLC7A5 (0.42) SLC7A5SLC1A3SLC1A2SLC1A1USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 128 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3303367-B1 STABILIZED MINIMAL COILED-COIL MIMETICS UNIV NEW YORK (US) 2025-06-18 EP claimed
US-20240101595-A1 SYSTEMS AND METHODS FOR MULTI-REAGENT CHEMICAL LABELING OF BIOLOGICAL MOLECULES CASE WESTERN RESERVE UNIVERSITY 2024-03-28 US claimed
WO-2022170024-A1 SYSTEMS AND METHODS FOR MULTI-REAGENT CHEMICAL LABELING OF BIOLOGICAL MOLECULES CASE WESTERN RESERVE UNIVERSITY (US) 2022-08-11 WO claimed
US-20130012690-A1 METHOD FOR STABILIZATION OF PROTEINS USING NON-NATURAL AMINO ACIDS CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2013-01-10 US claimed
US-20090221790-A1 METHOD FOR STABILIZATION OF PROTEINS USING NON-NATURAL AMINO ACIDS CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2009-09-03 US claimed
EP-4687443-A1 METHOD FOR FUNCTIONALISING A SOLID SUBSTRATE WITH A PEPTIDE CONJUGATE Genepep (FR) 2026-02-11 EP disclosed
US-20260001924-A1 NEMO COILED COIL MIMICS AND METHODS OF USING SAME NEW YORK UNIVERSITY (US) 2026-01-01 US disclosed
EP-4640217-A1 ANTICANCER AGENT AGC INC. (JP) 2025-10-29 EP disclosed
US-20250312303-A1 ANTICANCER AGENT AGC Inc. (JP) 2025-10-09 US disclosed
US-20250269046-A1 CELLULAR UPTAKE OF LARGE BIOMOLECULES ENABLED BY CELL-SURFACE-REACTIVE CELL-PENETRATING PEPTIDE ADDITIVES FORSCHUNGSVERBUND BERLIN E.V. (DE) 2025-08-28 US disclosed
US-12371461-B2 Nemo coiled coil mimics and methods of using same NEW YORK UNIVERSITY (US) 2025-07-29 US disclosed
EP-3303367-B1 STABILIZED MINIMAL COILED-COIL MIMETICS UNIV NEW YORK (US) 2025-06-18 EP disclosed
US-7132559-B2 Non-racemic hexafluoroleucine, and methods of making and using it TRUSTEES OF TUFTS COLLEGE (US) 2006-11-07 US disclosed
WO-2006103274-A1 AGE INHIBITORS PHARMAMENS (FR) 2006-10-05 WO disclosed
EP-1608638-A1 FLUORO-AND TRIFLUOROALKYL-CONTAINING HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION AND DERIVATIVES THEREOF Wyeth (US) 2005-12-28 EP disclosed
US-20050143422-A1 Biaryl sulfonamides and methods for using same WYETH (US) 2005-06-30 US disclosed
WO-2004092155-A1 FLUORO-AND TRIFLUOROALKYL-CONTAINING HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION AND DERIVATIVES THEREOF WYETH (US) 2004-10-28 WO disclosed
US-20040198778-A1 Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof WYETH 2004-10-07 US disclosed
US-20040138493-A1 Non-racemic hexafluoreleucine, and methods of making and using it TRUSTEES OF TUFTS COLLEGE 2004-07-15 US disclosed
WO-2002068592-A2 NON-RACEMIC HEXAFLUORELEUCINE, AND METHODS OF MAKING AND USING IT TRUSTEES OF TUFTS COLLEGE (US) 2002-09-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12371461-B2 Nemo coiled coil mimics and methods of using same COIL, CALCOCO2, NCAPH SLC7A5 3871/4885SLC1A3 1986/4885SLC1A2 2121/4885
US-20250269046-A1 CELLULAR UPTAKE OF LARGE BIOMOLECULES ENABLED BY CELL-SURFACE-REACTIVE CELL-PENETRATING PEPTIDE ADDITIVES GZMB, SLC7A5, SLC7A1 SLC7A5 2/4885SLC1A3 350/4885SLC1A2 317/4885
US-20050143422-A1 Biaryl sulfonamides and methods for using same STS, MMP3, AADAC SLC7A5 2395/4885SLC1A3 2163/4885SLC1A2 1852/4885
US-20040198778-A1 Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof BACE1, APP, PSEN1 SLC7A5 656/4885SLC1A3 2034/4885SLC1A2 2329/4885
US-20260001924-A1 NEMO COILED COIL MIMICS AND METHODS OF USING SAME DDX21, PHAX, RBX1 SLC7A5 3352/4885SLC1A3 2255/4885SLC1A2 2731/4885
US-20040138493-A1 Non-racemic hexafluoreleucine, and methods of making and using it NPFFR1, FNTB, CRYZ SLC7A5 1102/4885SLC1A3 2419/4885SLC1A2 1904/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.