Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.63 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.57 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21245824 | 0.88 | HTR2C (0.57) | HTR2CMTNR1AMTNR1BHTR2AKDM4E | |
| SCHEMBL5988329 | 0.88 | HTR2C (0.57) | HTR2CMTNR1AMTNR1BHTR2AKDM4E | |
| SCHEMBL18857024 | 0.85 | MTNR1A (0.62) | HTR2CMTNR1AMTNR1BHTR2AKDM4E | |
| SCHEMBL4204521 | 0.83 | MTNR1A (0.60) | HTR2CMTNR1AMTNR1BHTR2AKDM4E | |
| SCHEMBL18857020 | 0.83 | HTR2C (0.59) | HTR2CMTNR1AMTNR1BHTR2AKDM4E | |
| SCHEMBL3817124 | 0.83 | HTR2C (0.59) | HTR2CMTNR1AMTNR1BHTR2AKDM4E | |
| SCHEMBL10413240 | 0.82 | MTNR1A (0.59) | HTR2CMTNR1AMTNR1BHTR2AKDM4E | |
| SCHEMBL8463092 | 0.81 | HTR2C (0.57) | HTR2CMTNR1AMTNR1BHTR2AKDM4E | |
| SCHEMBL7232114 | 0.81 | HTR2C (0.64) | HTR2CMTNR1AMTNR1BHTR2AKDM4E | |
| SCHEMBL23956095 | 0.81 | HTR7 (0.67) | HTR2CMTNR1AMTNR1BHTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040224960-A1 | Pharmaceutical compositions and methods for their use | AGOURON PHARMACEUTICALS, INC. | 2004-11-11 | — | — | US | claimed |
| WO-2023139248-A1 | INHIBITORS OF ACYL PROTEIN THIOESTERASES AGAINST MICROBIAL INFECTIONS | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2023-07-27 | — | — | WO | disclosed |
| WO-2013006408-A1 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2013-01-10 | — | — | WO | disclosed |
| WO-2013006408-A1 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2013-01-10 | — | — | WO | disclosed |
| US-20040224960-A1 | Pharmaceutical compositions and methods for their use | AGOURON PHARMACEUTICALS, INC. | 2004-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040224960-A1 | Pharmaceutical compositions and methods for their use | CYP3A5, CYP3A7, CYP3A43 | HTR2C 1539/4885MTNR1A 797/4885MTNR1B 771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.