Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.52 |
| ▸ | NOS1 | P29475 | 1/20 | 0.52 |
| ▸ | NOS2 | P35228 | 1/20 | 0.52 |
| ▸ | IL33 | O95760 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | APAF1 | O14727 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6394577 | 0.77 | ALDH1A1 (0.47) | IL33KMT2AMAPTMAPK1ALDH1A1 | |
| SCHEMBL18862282 | 0.76 | IL33 (0.46) | IL33KMT2AMAPTMAPK1ALDH1A1 | |
| SCHEMBL18862279 | 0.74 | IL33 (0.52) | IL33KMT2AMAPTMAPK1ALDH1A1 | |
| SCHEMBL16316318 | 0.72 | ALDH1A1 (0.49) | IL33KMT2AMAPTMAPK1ALDH1A1 | |
| SCHEMBL18862278 | 0.70 | MAPT (0.59) | IL33KMT2AMAPTMAPK1ALDH1A1 | |
| SCHEMBL623536 | 0.70 | ALDH1A1 (0.52) | KMT2AMAPTMAPK1ALDH1A1NPC1 | |
| SCHEMBL622199 | 0.70 | ALDH1A1 (0.49) | IL33KMT2AMAPTMAPK1ALDH1A1 | |
| SCHEMBL13719371 | 0.69 | ALDH1A1 (0.46) | IL33KMT2AMAPTMAPK1ALDH1A1 | |
| SCHEMBL3400235 | 0.69 | ALDH1A1 (0.59) | KMT2AMAPTMAPK1ALDH1A1NPC1 | |
| SCHEMBL18862272 | 0.68 | IL33 (0.55) | IL33KMT2AMAPTMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017083242-A1 | INHIBITORS OF SUPPRESSION OF TUMORIGENCITY 2 (ST2) AND METHODS USING THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2017-05-18 | — | — | WO | disclosed |