Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | APAF1 | O14727 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL622199 | 0.84 | ALDH1A1 (0.49) | ALDH1A1KMT2AMAPTMAPK1MEN1 | |
| SCHEMBL16316318 | 0.84 | ALDH1A1 (0.49) | ALDH1A1KMT2AMAPTMAPK1MEN1 | |
| SCHEMBL3400235 | 0.83 | ALDH1A1 (0.59) | ALDH1A1KMT2AMAPTMAPK1MEN1 | |
| SCHEMBL6394577 | 0.81 | ALDH1A1 (0.47) | ALDH1A1KMT2AMAPTMAPK1MEN1 | |
| SCHEMBL13719371 | 0.81 | ALDH1A1 (0.46) | ALDH1A1KMT2AMAPTMAPK1MEN1 | |
| SCHEMBL18862278 | 0.76 | MAPT (0.59) | ALDH1A1KMT2AMAPTMAPK1MEN1 | |
| SCHEMBL6731238 | 0.76 | ALDH1A1 (0.52) | ALDH1A1KMT2AMAPTMAPK1MEN1 | |
| SCHEMBL6731240 | 0.76 | ALDH1A1 (0.52) | ALDH1A1KMT2AMAPTMAPK1MEN1 | |
| SCHEMBL2089396 | 0.75 | SLC9A1 (0.67) | ALDH1A1KMT2AMAPTMAPK1MEN1 | |
| SCHEMBL3327335 | 0.74 | SLC9A1 (0.65) | ALDH1A1KMT2AMAPTMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9255088-B2 | Premature-termination-codons readthrough compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-02-09 | — | — | US | disclosed |
| US-9255088-B2 | Premature-termination-codons readthrough compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-02-09 | — | — | US | disclosed |
| US-20130274283-A1 | PREMATURE-TERMINATION-CODONS READTHROUGH COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-10-17 | — | — | US | disclosed |
| US-20130274283-A1 | PREMATURE-TERMINATION-CODONS READTHROUGH COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-10-17 | — | — | US | disclosed |
| US-20130274283-A1 | PREMATURE-TERMINATION-CODONS READTHROUGH COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-10-17 | — | — | US | disclosed |
| WO-2012021707-A2 | PREMATURE-TERMINATION-CODONS READTHROUGH COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-02-16 | — | — | WO | disclosed |
| WO-2012021707-A2 | PREMATURE-TERMINATION-CODONS READTHROUGH COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-02-16 | — | — | WO | disclosed |
| EP-1474387-B1 | DERIVATIVES OF ALPHA-PHENYLTHIOCARBOXYLIC AND ALPHA-PHENYLOXY-CARBOXYLIC ACIDS USEFUL FOR THE TREATMENT OF DISEASES RESPONDING TO PPAR ALPHA ACTIVATION | SIGMA TAU IND FARMACEUTI (IT) | 2010-11-24 | — | — | EP | disclosed |
| CN-100522940-C | Derivatives of alpha-phenylthiocarboxylic and g(a)-phenyloxy-carboxylic acids useful for the treatment of diseases responding to PPAR alpha activation | SIGMA TAU IND FARMACEUTI (IT) | 2009-08-05 | — | — | CN | disclosed |
| US-20080027098-A1 | Derivatives of alpha-phenylthiocarboxylic and alpha-phenyloxy-carboxylic acids useful for the treatment of diseases responding to PPARalpha activation | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-01-31 | — | — | US | disclosed |
| CN-1620429-A | Derivatives of alpha-phenylthiocarboxylic and g(a)-phenyloxy-carboxylic acids useful for the treatment of diseases responding to PPAR alpha activation | SIGMA TAU IND FARMACEUTI (IT) | 2005-05-25 | — | — | CN | disclosed |
| US-20050054671-A1 | Derivatives of alpha-phenylthiocarboxylic and $g(a)-phenyloxy-carboxylic acids useful for the treatment of diseases responding to pparalpha activation | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P. A | 2005-03-10 | — | — | US | disclosed |
| EP-1474387-A2 | DERIVATIVES OF ALPHA-PHENYLTHIOCARBOXYLIC AND ALPHA-PHENYLOXY-CARBOXYLIC ACIDS USEFUL FOR THE TREATMENT OF DISEASES RESPONDING TO PPAR ALPHA ACTIVATION | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 2004-11-10 | — | — | EP | disclosed |
| WO-2003059875-A2 | DERIVATIVES OF α-PHENYLTHIOCARBOXYLIC AND α-PHENYLOXY-CARBOXYLIC ACIDS USEFUL FOR THE TREATMENT OF DISEASES RESPONDING TO PPARα ACTIVATION | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2003-07-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130274283-A1 | PREMATURE-TERMINATION-CODONS READTHROUGH COMPOUNDS | UPF1, NUDT21, RNGTT | ALDH1A1 4427/4885KMT2A 1956/4885MAPT 4401/4885 |
| US-20080027098-A1 | Derivatives of alpha-phenylthiocarboxylic and alpha-phenyloxy-carboxylic acids useful for the treatment of diseases responding to PPARalpha activation | PPARA, PPARD, PPARG | ALDH1A1 685/4885KMT2A 3263/4885MAPT 3247/4885 |
| US-20050054671-A1 | Derivatives of alpha-phenylthiocarboxylic and $g(a)-phenyloxy-carboxylic acids useful for the treatment of diseases responding to pparalpha activation | PPARG, PPARA, PPARD | ALDH1A1 841/4885KMT2A 2309/4885MAPT 3386/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.