Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL33 | O95760 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | APAF1 | O14727 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18862278 | 0.84 | MAPT (0.59) | IL33ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL18862275 | 0.82 | KDM4E (0.59) | IL33ALDH1A1MAPTMAPK1L3MBTL1 | |
| SCHEMBL18862279 | 0.78 | IL33 (0.52) | IL33ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL15347324 | 0.72 | ALDH1A1 (0.53) | IL33ALDH1A1MAPTMAPK1L3MBTL1 | |
| SCHEMBL623536 | 0.72 | ALDH1A1 (0.52) | ALDH1A1MAPTNPC1RAB9AMAPK1 | |
| SCHEMBL18862291 | 0.71 | IL33 (1.00) | IL33ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL16316318 | 0.70 | ALDH1A1 (0.49) | IL33ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL622199 | 0.70 | ALDH1A1 (0.49) | IL33ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL17589740 | 0.70 | IL33 (0.46) | IL33ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL18862228 | 0.70 | IL33 (0.46) | IL33ALDH1A1MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017083242-A1 | INHIBITORS OF SUPPRESSION OF TUMORIGENCITY 2 (ST2) AND METHODS USING THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2017-05-18 | — | — | WO | disclosed |