Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | IL33 | O95760 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18862272 | 0.82 | IL33 (0.55) | KDM4EPKMKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL18862278 | 0.77 | MAPT (0.59) | KDM4ECYP1A2CYP3A4CYP2C9PKM | |
| SCHEMBL18862279 | 0.74 | IL33 (0.52) | KDM4EPKMKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3435049 | 0.74 | ALDH1A1 (0.70) | KDM4ECYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL28972131 | 0.73 | ALDH1A1 (0.61) | KDM4ECYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL28972130 | 0.73 | ALDH1A1 (0.61) | KDM4ECYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL31687195 | 0.73 | ALDH1A1 (0.61) | KDM4ECYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL1946258 | 0.73 | L3MBTL1 (0.86) | KDM4EALDH1A1SMN1; SMN2ATML3MBTL1 | |
| Bromide SCHEMBL10462008 | 0.72 | L3MBTL1 (0.84) | KDM4EALDH1A1SMN1; SMN2ATML3MBTL1 | |
| SCHEMBL18862291 | 0.69 | IL33 (1.00) | KDM4EPKMKMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017083242-A1 | INHIBITORS OF SUPPRESSION OF TUMORIGENCITY 2 (ST2) AND METHODS USING THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2017-05-18 | — | — | WO | disclosed |