Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.55 |
| ▸ | MMP13 | P45452 | 1/20 | 0.55 |
| ▸ | LTA4H | P09960 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.54 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.54 |
| ▸ | BAX | Q07812 | 1/20 | 0.54 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | PNLIP | P16233 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12355 | 0.91 | HTT (0.69) | SMN1; SMN2HTTMAPK14EPHX2LTA4H | |
| SCHEMBL17081753 | 0.91 | HTT (0.69) | SMN1; SMN2HTTMAPK14EPHX2LTA4H | |
| SCHEMBL425356 | 0.91 | HTT (0.69) | SMN1; SMN2HTTMAPK14EPHX2LTA4H | |
| Toluene SCHEMBL8854763 | 0.88 | HTT (0.67) | SMN1; SMN2HTTMAPK14EPHX2LTA4H | |
| Diphenylether SCHEMBL9008689 | 0.88 | LTA4H (0.71) | SMN1; SMN2HTTMAPK14LTA4HTSHR | |
| SCHEMBL13375679 | 0.88 | SRD5A2 (0.72) | SMN1; SMN2HTTMAPK14EPHX2PARP10 | |
| Phthalic Acid SCHEMBL10983920 | 0.88 | AKR1C3 (0.59) | SMN1; SMN2HTTMAPK14EPHX2PARP10 | |
| Phosphoric Acid SCHEMBL5518515 | 0.87 | HTT (0.61) | SMN1; SMN2HTTMAPK14EPHX2PARP10 | |
| Formic Acid SCHEMBL18406225 | 0.87 | HTT (0.61) | SMN1; SMN2HTTMAPK14EPHX2PARP10 | |
| SCHEMBL16741276 | 0.86 | SMN1; SMN2 (0.60) | SMN1; SMN2HTTMAPK14EPHX2MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112225944-B | LDS (laser direct structuring) additive with good dispersibility, LDS material containing additive and application | 中国石油化工股份有限公司 | 2022-07-12 | — | — | CN | disclosed |
| EP-2552995-B2 | MELT POLYCARBONATE HAVING IMPROVED HEAT AGEING | COVESTRO DEUTSCHLAND AG (DE) | 2022-01-05 | — | — | EP | disclosed |
| CN-113880995-A | Modified polycarbonate and preparation method and application thereof | 中国石油化工股份有限公司 | 2022-01-04 | — | — | CN | disclosed |
| CN-113348006-A | Crack-resistant member | 株式会社大赛璐 | 2021-09-03 | — | — | CN | disclosed |
| CN-112226081-A | Laser-sensitized resin composition, and preparation method and application thereof | 中国石油化工股份有限公司 | 2021-01-15 | — | — | CN | disclosed |
| CN-112225944-A | LDS (laser direct structuring) additive with good dispersibility, LDS material containing additive and application | 中国石油化工股份有限公司 | 2021-01-15 | — | — | CN | disclosed |
| EP-2552995-B1 | MELT POLYCARBONATE HAVING IMPROVED HEAT AGEING | COVESTRO DEUTSCHLAND AG (DE) | 2015-12-02 | — | — | EP | disclosed |
| US-8716380-B2 | Polycarbonate composition having improved heat stability | BAYER MATERIALSCIENCE AG (DE) | 2014-05-06 | — | — | US | disclosed |
| US-8487025-B2 | Branched melt polycarbonate with low content of defective structures | BAYER MATERIAL SCIENCE AG (DE) | 2013-07-16 | — | — | US | disclosed |
| EP-2552995-A1 | MELT POLYCARBONATE HAVING IMPROVED HEAT AGEING | Bayer Intellectual Property GmbH (DE) | 2013-02-06 | — | — | EP | disclosed |
| US-8163822-B2 | Polycarbonate composition with improved melt-flowability | BAYER MATERIALSCIENCE AG (DE) | 2012-04-24 | — | — | US | disclosed |
| US-20110251309-A1 | BRANCHED MELT POLYCARBONATE WITH LOW CONTENT OF DEFECTIVE STRUCTURES | BAYER MATERIALSCIENCE AG (DE) | 2011-10-13 | — | — | US | disclosed |
| WO-2011120921-A1 | MELT POLYCARBONATE HAVING IMPROVED HEAT AGEING | BAYER MATERIALSCIENCE AG (DE) | 2011-10-06 | — | — | WO | disclosed |
| WO-2011120198-A1 | MELT POLYCARBONATE HAVING IMPROVED HEAT AGEING RESISTANCE AND MANUFACTURING METHOD THEREOF | BAYER MATERIALSCIENCE AG (DE) | 2011-10-06 | — | — | WO | disclosed |
| US-20110130500-A1 | POLYCARBONATE COMPOSITION HAVING IMPROVED HEAT STABILITY | BAYER MATERIALSCIENCE AG (DE) | 2011-06-02 | — | — | US | disclosed |
| US-20110105659-A1 | POLYCARBONATE COMPOSITION WITH IMPROVED MELT-FLOWABILITY | BAYER MATERIALSCIENCE AG (DE) | 2011-05-05 | — | — | US | disclosed |
| US-6699959-B2 | EXHIBITS A FLOW BEHAVIOR SIMILAR TO THAT OF A LINEAR POLYCARBONATE OF COMPARABLE MOLECULAR WEIGHT OBTAINED BY THE INTERFACE POLYMERIZATION PROCESS. | BAYER AKTIENGESELLSCHAFT (DE) | 2004-03-02 | — | — | US | disclosed |
| US-20030027973-A1 | Polycarbonate having a low shear thinning behavior | BAYER AKTIENGESELLSCHAFT (DE) | 2003-02-06 | — | — | US | disclosed |
| US-4371660-A | Anisotropic melt phase forming poly(ester-carbonate) derived from 6-hydroxy-2-napthoic acid, aromatic diol, organic compound capable of forming a carbonate linkage, and, optionally, other aromatic hydroxy-acid and carbocyclic dicarboxylic acid | CELANESE CORPORATION (US) | 1983-02-01 | — | — | US | disclosed |
| US-3946033-A | FROM GLYCINE DERIVATIVE, PRIMARY AMINE, DIARYL CARBONATE | TEIJIN LTD. (JA) | 1976-03-23 | — | — | US | disclosed |