SCHEMBL18864591

SCHEMBL18864591

CS(=O)(=O)OCCC(F)(F)CCOS(C)(=O)=O

nearest known ligand 0.52

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
USP2 O75604 2/20 0.52
TSHR P16473 2/20 0.52
KDM4E B2RXH2 1/20 0.52
ALDH1A1 P00352 1/20 0.52
LMNA P02545 1/20 0.52
MMP9 P14780 1/20 0.52
ALOX15 P16050 1/20 0.52
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA9 Q16790 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9826622 0.89 USP2 (0.46) USP2TSHRKDM4EALDH1A1LMNA
SCHEMBL3370980 0.85 USP2 (0.52) USP2TSHRKDM4EALDH1A1LMNA
SCHEMBL9111200 0.83 USP2 (0.50) USP2TSHRKDM4EALDH1A1LMNA
SCHEMBL3595211 0.77 USP2 (0.55) USP2TSHRKDM4EALDH1A1LMNA
SCHEMBL2077428 0.76 USP2 (0.61) USP2TSHRKDM4EALDH1A1LMNA
SCHEMBL1614405 0.75 USP2 (0.58) USP2TSHRKDM4EALDH1A1LMNA
SCHEMBL4473443 0.74 MMP9 (0.41) USP2TSHRKDM4EALDH1A1LMNA
Ethane Dimethane Sulfonate SCHEMBL1336145 0.74 USP2 (0.75) USP2TSHRKDM4EALDH1A1LMNA
SCHEMBL14844857 0.74 USP2 (0.43) USP2TSHRKDM4EALDH1A1LMNA
SCHEMBL3369383 0.73 ALDH1A1 (0.50) USP2TSHRKDM4EALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12570625-B2 3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof NOVARTIS AG (CH) 2026-03-10 US disclosed
EP-3888658-B1 EIF4-A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EFFECTOR THERAPEUTICS INC (US) 2023-12-27 EP disclosed
US-20230295179-A1 EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EFFECTOR THERAPEUTICS, INC. 2023-09-21 US disclosed
US-20230295179-A1 EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EFFECTOR THERAPEUTICS, INC. 2023-09-21 US disclosed
US-20230295179-A1 EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EFFECTOR THERAPEUTICS, INC. 2023-09-21 US disclosed
US-20230071483-A1 EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO OXFORD FINANCE LLC, AS COLLATERAL AGENT 2023-03-09 US disclosed
US-20230071483-A1 EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO OXFORD FINANCE LLC, AS COLLATERAL AGENT 2023-03-09 US disclosed
US-20230067476-A1 3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF NOVARTIS AG (CH) 2023-03-02 US disclosed
US-11440917-B2 EIF4A-inhibiting compounds and methods related thereto EFFECTOR THERAPEUTICS, INC. (US) 2022-09-13 US disclosed
CN-108601788-B EIF 4A-inhibiting compounds and methods relating thereto 效应治疗股份有限公司 2021-10-22 CN disclosed
US-20180298017-A1 EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EFFECTOR THERAPEUTICS, INC. (US) 2018-10-18 US disclosed
EP-3380101-A1 EIF4-A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO Effector Therapeutics Inc. (US) 2018-10-03 EP disclosed
US-9957277-B2 eIF4A-inhibiting compounds and methods related thereto EFFECTOR THERAPEUTICS, INC. (US) 2018-05-01 US disclosed
US-9957277-B2 eIF4A-inhibiting compounds and methods related thereto EFFECTOR THERAPEUTICS, INC. (US) 2018-05-01 US disclosed
US-9957277-B2 eIF4A-inhibiting compounds and methods related thereto EFFECTOR THERAPEUTICS, INC. (US) 2018-05-01 US disclosed
WO-2017091585-A1 EIF4-A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EFFECTOR THERAPEUTICS, INC. (US) 2017-06-01 WO disclosed
WO-2017091585-A1 EIF4-A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EFFECTOR THERAPEUTICS, INC. (US) 2017-06-01 WO disclosed
US-20170145026-A1 EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EFFECTOR THERAPEUTICS, INC. 2017-05-25 US disclosed
US-20170145026-A1 EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EFFECTOR THERAPEUTICS, INC. 2017-05-25 US disclosed
US-20170145026-A1 EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EFFECTOR THERAPEUTICS, INC. 2017-05-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230295179-A1 EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EIF4A1, EIF4A2, EIF4A3 USP2 2925/4885TSHR 3587/4885KDM4E 812/4885
US-20230071483-A1 EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EIF4A1, EIF4A2, EIF4A3 USP2 2925/4885TSHR 3587/4885KDM4E 812/4885
US-12570625-B2 3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof IKZF1, IKZF2, BCL6 USP2 329/4885TSHR 3099/4885KDM4E 2086/4885
US-11440917-B2 EIF4A-inhibiting compounds and methods related thereto EIF4A1, EIF4A2, EIF4A3 USP2 2925/4885TSHR 3587/4885KDM4E 812/4885
US-20230067476-A1 3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF XDH, HTR1D, RXFP1 USP2 2052/4885TSHR 1451/4885KDM4E 3010/4885
US-20180298017-A1 EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EIF4A1, EIF4A2, EIF4A3 USP2 2925/4885TSHR 3587/4885KDM4E 812/4885
US-20170145026-A1 EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO EIF4A1, EIF4A2, EIF4A3 USP2 2925/4885TSHR 3587/4885KDM4E 812/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.