SCHEMBL18869481

SCHEMBL18869481

C=C(C)C(=O)Oc1ccc(-c2ccc(OC)cc2)c(F)c1F

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 3/20 0.49
MAPT P10636 1/20 0.43
SMN1; SMN2 Q16637 2/20 0.42
CYP2C19 P33261 2/20 0.41
KDM4E B2RXH2 2/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C9 P11712 1/20 0.41
APP P05067 1/20 0.41
ELANE P08246 1/20 0.38
PTGDR2 Q9Y5Y4 1/20 0.38
TUBB4A P04350 1/20 0.38
TUBB P07437 1/20 0.38
TUBA3C P0DPH7 1/20 0.38
TUBA1B P68363 1/20 0.38
TUBA4A P68366 1/20 0.38
TUBB4B P68371 1/20 0.38
TUBB3 Q13509 1/20 0.38
TUBB2A Q13885 1/20 0.38
TUBB8 Q3ZCM7 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18699588 0.92 BACE1 (0.48) BACE1MAPTSMN1; SMN2CYP2C19KDM4E
SCHEMBL9607785 0.92 ELANE (0.47) BACE1MAPTSMN1; SMN2CYP2C19KDM4E
SCHEMBL12196860 0.90 ELANE (0.43) BACE1MAPTSMN1; SMN2CYP2C19KDM4E
SCHEMBL22600459 0.85 THRB (0.40) BACE1ELANEHSD17B10KMT2AATM
SCHEMBL18437063 0.85 ELANE (0.36) BACE1ELANEKMT2AATM
SCHEMBL9607858 0.85 ELANE (0.51) BACE1MAPTSMN1; SMN2CYP2C19KDM4E
SCHEMBL18411591 0.84 ELANE (0.44) BACE1ELANEKMT2AATM
SCHEMBL21165409 0.84 GPR174 (0.40) MAPTSMN1; SMN2CYP2C19KDM4ECYP1A2
SCHEMBL18522769 0.84 ELANE (0.35) BACE1CYP2C19APPELANEKMT2A
SCHEMBL12196857 0.84 ELANE (0.36) MAPTKDM4ECYP1A2CYP2C9ELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4306614-A1 LIQUID-CRYSTALLINE MEDIUM Merck Patent GmbH (DE) 2024-01-17 EP disclosed
EP-4306615-A1 LIQUID-CRYSTAL MEDIUM Merck Patent GmbH (DE) 2024-01-17 EP disclosed
EP-3839008-B1 LIQUID CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2023-07-26 EP disclosed
EP-3489329-B1 LIQUID CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2022-01-12 EP disclosed
EP-3848436-A1 LIQUID-CRYSTAL MEDIUM Merck Patent GmbH (DE) 2021-07-14 EP disclosed
EP-3839008-A1 LIQUID CRYSTAL MEDIUM Merck Patent GmbH (DE) 2021-06-23 EP disclosed
EP-3839620-A1 DEVICE FOR THE REGULATION OF LIGHT TRANSMISSION Merck Patent GmbH (DE) 2021-06-23 EP disclosed
EP-3688118-B1 POLYMERISABLE COMPOUNDS AND THE USE THEREOF IN LIQUID-CRYSTAL DISPLAYS MERCK PATENT GMBH (DE) 2021-05-19 EP disclosed
EP-3587536-B1 LIQUID CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2021-03-24 EP disclosed
EP-3757192-A1 LIQUID CRYSTALLINE MEDIUM Merck Patent GmbH (DE) 2020-12-30 EP disclosed
EP-3048159-B1 LIQUID CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2019-08-07 EP disclosed
EP-3489329-A1 LIQUID CRYSTALLINE MEDIUM Merck Patent GmbH (DE) 2019-05-29 EP disclosed
EP-3067406-B1 LIQUID CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2019-04-24 EP disclosed
EP-2957618-B1 LIQUID CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2018-08-01 EP disclosed
EP-2703472-B1 Liquid crystalline medium MERCK PATENT GMBH (DE) 2018-07-04 EP disclosed
EP-3339396-A1 LIQUID CRYSTAL DISPLAY DEVICE AND LIQUID CRYSTAL COMPOSITION INCLUDED THEREIN Samsung Display Co., Ltd. (KR) 2018-06-27 EP disclosed
EP-2985334-B1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2018-06-20 EP disclosed
EP-2837671-B1 Liquid crystalline medium MERCK PATENT GMBH (DE) 2017-10-25 EP disclosed
EP-2691490-B1 LIQUID CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2017-07-26 EP disclosed
EP-2628779-B1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2017-05-17 EP disclosed