Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 11/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 8/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | STAT1 | P42224 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18871984 | 0.87 | CYP11B2 (0.56) | CYP11B2CYP11B1NOTUMPDK1PDK2 | |
| SCHEMBL20429095 | 0.83 | CYP11B2 (0.50) | CYP11B2CYP11B1NOTUMLMNATP53 | |
| SCHEMBL18871783 | 0.83 | CYP11B2 (0.51) | CYP11B2CYP11B1NOTUMPDK1PDK2 | |
| SCHEMBL18871976 | 0.82 | LMNA (0.58) | CYP11B2CYP11B1KDM4ENOTUMPDK1 | |
| SCHEMBL20429098 | 0.81 | CYP11B2 (0.47) | CYP11B2CYP11B1NOTUMLMNATP53 | |
| SCHEMBL20429027 | 0.81 | CYP11B2 (0.47) | CYP11B2CYP11B1NOTUMLMNATP53 | |
| SCHEMBL18872002 | 0.81 | CYP11B2 (0.49) | CYP11B2CYP11B1NOTUMPDK1PDK2 | |
| SCHEMBL18871765 | 0.81 | PDK1 (0.50) | KDM4EPDK1PDK2PDK3PDK4 | |
| SCHEMBL18871999 | 0.80 | CYP11B2 (0.48) | CYP11B2CYP11B1NOTUMLMNATP53 | |
| SCHEMBL20429091 | 0.80 | CYP11B2 (0.48) | CYP11B2CYP11B1NOTUMPDK1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3168213-B1 | TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2018-08-01 | — | — | EP | disclosed |
| EP-3168213-A1 | TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | Glaxosmithkline LLC (US) | 2017-05-17 | — | — | EP | disclosed |