Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 11/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 8/20 | 0.49 |
| ▸ | RORC | P51449 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18871997 | 0.90 | CYP11B2 (0.46) | CYP11B2CYP11B1ALDH1A1LMNATSHR | |
| SCHEMBL20429027 | 0.86 | CYP11B2 (0.47) | CYP11B2CYP11B1ALDH1A1LMNATSHR | |
| SCHEMBL20429098 | 0.86 | CYP11B2 (0.47) | CYP11B2CYP11B1ALDH1A1LMNATSHR | |
| SCHEMBL20429028 | 0.85 | CYP11B2 (0.56) | CYP11B2CYP11B1RORCALDH1A1LMNA | |
| SCHEMBL18871984 | 0.84 | CYP11B2 (0.56) | CYP11B2CYP11B1ALDH1A1LMNATSHR | |
| SCHEMBL20429089 | 0.83 | CYP11B2 (0.52) | CYP11B2CYP11B1RORCALDH1A1LMNA | |
| SCHEMBL18871771 | 0.83 | CYP11B2 (0.53) | CYP11B2CYP11B1ALDH1A1LMNATSHR | |
| SCHEMBL18871832 | 0.82 | PDK1 (0.49) | ALDH1A1 | |
| SCHEMBL18871783 | 0.79 | CYP11B2 (0.51) | CYP11B2CYP11B1ALDH1A1LMNATSHR | |
| SCHEMBL18871995 | 0.79 | LMNA (0.54) | CYP11B2CYP11B1ALDH1A1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3168213-B1 | TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2018-08-01 | — | — | EP | disclosed |