Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 6/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.49 |
| ▸ | RORC | P51449 | 1/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18871772 | 0.85 | CYP11B2 (0.54) | CYP11B2CYP11B1ALDH1A1HPGD | |
| SCHEMBL18871839 | 0.84 | HRH3 (0.55) | HRH3SMN1; SMN2 | |
| SCHEMBL18872002 | 0.82 | CYP11B2 (0.49) | CYP11B2RORCCYP11B1SMN1; SMN2ALDH1A1 | |
| SCHEMBL20429089 | 0.78 | CYP11B2 (0.52) | CYP11B2RORCCYP11B1ALDH1A1HPGD | |
| SCHEMBL18871988 | 0.76 | FYN (0.45) | CYP11B2CYP11B1ALDH1A1 | |
| SCHEMBL15450340 | 0.75 | HRH3 (0.49) | HRH3SMN1; SMN2ALDH1A1 | |
| SCHEMBL5427259 | 0.75 | ALDH1A1 (0.54) | CYP11B2CYP11B1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL5458241 | 0.74 | HRH3 (0.58) | HRH3SMN1; SMN2 | |
| SCHEMBL20288815 | 0.74 | CYP11B2 (0.50) | CYP11B2CYP11B1SMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL15437438 | 0.74 | HRH3 (0.49) | HRH3SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3168213-B1 | TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2018-08-01 | — | — | EP | disclosed |
| EP-3168213-A1 | TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | Glaxosmithkline LLC (US) | 2017-05-17 | — | — | EP | disclosed |