Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 11/20 | 0.54 |
| ▸ | CYP11B1 | P15538 | 9/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.48 |
| ▸ | P4HA1 | P13674 | 2/20 | 0.47 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | LDHA | P00338 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18871773 | 0.85 | CYP11B2 (0.54) | CYP11B2CYP11B1ALDH1A1HPGD | |
| SCHEMBL20429089 | 0.85 | CYP11B2 (0.52) | CYP11B2CYP11B1NOTUMTP53ALDH1A1 | |
| SCHEMBL18871768 | 0.84 | CYP11B1 (0.58) | CYP11B2CYP11B1NOTUMTP53ALDH1A1 | |
| SCHEMBL18871988 | 0.82 | FYN (0.45) | CYP11B2CYP11B1TP53ALDH1A1LMNA | |
| SCHEMBL18871982 | 0.81 | PDK1 (0.55) | P4HA1P4HTM | |
| SCHEMBL20894496 | 0.81 | NOTUM (0.62) | NOTUMTP53ALDH1A1KDM4EHPGD | |
| SCHEMBL29631031 | 0.81 | NOTUM (0.62) | NOTUMTP53ALDH1A1KDM4EHPGD | |
| SCHEMBL18871984 | 0.80 | CYP11B2 (0.56) | CYP11B2CYP11B1NOTUMTP53ALDH1A1 | |
| SCHEMBL20288815 | 0.79 | CYP11B2 (0.50) | CYP11B2CYP11B1NOTUMTP53ALDH1A1 | |
| SCHEMBL20288527 | 0.78 | CYP11B2 (0.49) | CYP11B2CYP11B1NOTUMTP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3168213-A1 | TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | Glaxosmithkline LLC (US) | 2017-05-17 | — | — | EP | disclosed |