Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 9/20 | 0.52 |
| ▸ | RORC | P51449 | 2/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.42 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.42 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.42 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.42 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.42 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18871988 | 0.90 | FYN (0.45) | CYP11B2CYP11B1ALDH1A1LMNAFYN | |
| SCHEMBL20429028 | 0.87 | CYP11B2 (0.56) | CYP11B2RORCCYP11B1ALDH1A1LMNA | |
| SCHEMBL18871772 | 0.85 | CYP11B2 (0.54) | CYP11B2CYP11B1ALDH1A1LMNAHPGD | |
| SCHEMBL20429095 | 0.83 | CYP11B2 (0.50) | CYP11B2RORCCYP11B1ALDH1A1LMNA | |
| SCHEMBL18871843 | 0.83 | PDK1 (0.47) | CYP11B2ALDH1A1FYN | |
| SCHEMBL18872016 | 0.78 | PRKAB2 (0.51) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL18871844 | 0.78 | CYP11B2 (0.51) | CYP11B2RORCCYP11B1ALDH1A1LMNA | |
| SCHEMBL18871773 | 0.78 | CYP11B2 (0.54) | CYP11B2RORCCYP11B1ALDH1A1HPGD | |
| SCHEMBL20429019 | 0.76 | CYP11B2 (0.47) | CYP11B2RORCCYP11B1ALDH1A1LMNA | |
| SCHEMBL18871784 | 0.76 | TP53 (0.49) | CYP11B2RORCCYP11B1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3168213-B1 | TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2018-08-01 | — | — | EP | disclosed |