Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20429030 | 0.91 | LMNA (0.53) | LMNAALDH1A1TP53MEN1KMT2A | |
| SCHEMBL18871987 | 0.90 | LMNA (0.49) | LMNAALDH1A1TP53MEN1KMT2A | |
| SCHEMBL20429028 | 0.85 | CYP11B2 (0.56) | LMNAALDH1A1TP53TSHRL3MBTL1 | |
| SCHEMBL20429013 | 0.84 | LMNA (0.48) | LMNAALDH1A1TP53MEN1KMT2A | |
| SCHEMBL18871770 | 0.83 | CYP11B1 (0.54) | LMNAALDH1A1TP53MEN1KMT2A | |
| SCHEMBL26079790 | 0.80 | ALDH1A1 (0.57) | LMNAALDH1A1TP53MEN1KMT2A | |
| SCHEMBL26079792 | 0.80 | ALDH1A1 (0.57) | LMNAALDH1A1TP53MEN1KMT2A | |
| SCHEMBL20429095 | 0.79 | CYP11B2 (0.50) | LMNAALDH1A1TP53TSHRL3MBTL1 | |
| SCHEMBL20429088 | 0.78 | SMN1; SMN2 (0.51) | LMNAALDH1A1TP53MEN1KMT2A | |
| SCHEMBL18871768 | 0.75 | CYP11B1 (0.58) | LMNAALDH1A1TP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3168213-A1 | TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | Glaxosmithkline LLC (US) | 2017-05-17 | — | — | EP | disclosed |