Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | MPI | P34949 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18874400 | 0.90 | LPAR1 (0.50) | POLBLPAR1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1561331 | 0.86 | LPAR1 (0.58) | POLBLPAR1MAPTNAMPTNPC1 | |
| SCHEMBL18874178 | 0.85 | LMNA (0.44) | POLBLPAR1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL18874335 | 0.82 | POLB (0.45) | POLBLPAR1PKMMEN1KMT2A | |
| SCHEMBL1561320 | 0.76 | LPAR1 (0.66) | LPAR1NPC1RAB9A | |
| SCHEMBL18874035 | 0.75 | LPAR1 (0.53) | POLBLPAR1PKMMEN1KMT2A | |
| SCHEMBL18874043 | 0.74 | LPAR1 (0.48) | POLBLPAR1NPC1RAB9A | |
| SCHEMBL18874186 | 0.73 | LPAR1 (0.49) | POLBLPAR1NPC1RAB9A | |
| SCHEMBL18874338 | 0.73 | LPAR1 (0.47) | POLBLPAR1NPC1RAB9A | |
| SCHEMBL18873947 | 0.73 | LPAR1 (0.47) | POLBLPAR1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2303270-B1 | ACYLAMINO-SUBSTITUTED FUSED CYCLOPENTANECARBOXYLIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI SA (FR) | 2017-05-17 | — | — | EP | disclosed |