Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 2/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.35 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18878163 | 0.80 | DPP4 (0.43) | DPP4DPP8DPP9MAPTTSHR | |
| SCHEMBL18863242 | 0.77 | TDP1 (0.42) | TDP1VCAM1MAPTTSHRTP53 | |
| SCHEMBL23089572 | 0.76 | TDP1 (0.39) | TDP1VCAM1MAPTL3MBTL1TSHR | |
| SCHEMBL18863158 | 0.76 | VCAM1 (0.40) | TDP1VCAM1MAPTL3MBTL1KDM4E | |
| SCHEMBL30173025 | 0.71 | TDP1 (0.39) | TDP1VCAM1MAPTTSHRTP53 | |
| SCHEMBL18882824 | 0.71 | TDP1 (0.39) | TDP1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL23089544 | 0.70 | LMNA (0.38) | TDP1VCAM1MAPTCYP3A4HPGD | |
| SCHEMBL18863279 | 0.68 | ALDH1A1 (0.34) | MAPTCYP3A4HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL18863277 | 0.66 | MEN1 (0.42) | TDP1MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL18863248 | 0.64 | KAT2B (0.34) | TDP1F2VCAM1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180170916-A1 | INHIBITORS OF CXCR2 | CHEMOCENTRYX, INC. | 2018-06-21 | — | — | US | disclosed |
| US-9809581-B2 | Inhibitors of CXCR2 | CHEMOCENTRYX, INC. (US) | 2017-11-07 | — | — | US | disclosed |
| US-9809581-B2 | Inhibitors of CXCR2 | CHEMOCENTRYX, INC. (US) | 2017-11-07 | — | — | US | disclosed |
| US-20170144996-A1 | INHIBITORS OF CXCR2 | CHEMOCENTRYX, INC. | 2017-05-25 | — | — | US | disclosed |
| US-20170144996-A1 | INHIBITORS OF CXCR2 | CHEMOCENTRYX, INC. | 2017-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170144996-A1 | INHIBITORS OF CXCR2 | CXCR2, CXCR3, CXCR1 | DPP4 2511/4885DPP8 779/4885DPP9 960/4885 |
| US-20180170916-A1 | INHIBITORS OF CXCR2 | CXCR2, CXCR3, CXCR1 | DPP4 2514/4885DPP8 781/4885DPP9 960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.